NUNZIUM

Gut microbiota is the collection of bacteria, viruses and fungi in the human digestive tract. The gut microbiota has broad impacts, including protection against pathogens, maintaining the intestinal epithelium, metabolizing dietary and pharmaceutical compounds, and controlling immune function and behaviour. The microbial composition of the gut microbiota varies across regions of the digestive tract. The colon contains the highest microbes density recorded in any habitat on Earth, representing between 300 and 1000 different species. Bacteria are the largest and, to date, the best-studied component - 99% of gut bacteria - is made of about 30 to 40 species. The relationship between gut microbiota and humans is not merely a non-harmful coexistence but rather a mutualism. Some human gut microorganisms benefit the host by fermenting dietary fibres and also play a role in synthesizing vitamin B and vitamin K and metabolizing bile acids, sterols and synthetic chemicals. Dysregulation of the gut microbiota has been linked with several diseases, such as asthma, bowel inflammatory disease, autoimmune diseases and even depression. Recently, a study has established a strong link with a dangerous but common type of diabetes.

Gestational Diabetes Mellitus (GDM) is when women without diabetes are diagnosed with glucose intolerance during pregnancy, typically in the second or third trimester. Approximately 10% of pregnant women worldwide are diagnosed with GDM. Risk factors include increased maternal age, obesity, family history of diabetes and history of giving birth to large infants. Consequences of GDM have a wide range of complications for both the mother (e.g., pre-eclampsia, type 2 diabetes and cardiovascular diseases) and the neonate (e.g., macrosomia and hypo-glycaemia). Many complications are preventable if GDM is detected and appropriately managed. Reasonable control is achieved by nutrition, exercise and insulin administration - if necessary - along with heightened monitoring during labour and delivery. However, an earlier detection (for example, during the first trimester) may allow for an anticipated action, possibly reducing GDM-associated short and long-term risks.

A study published in the scientific journal Gut shows that gut microbiota plays a role in GDM pathogenesis. In particular, scientists profiled the gut microbiota and clinical records of 394 women during the first trimester of pregnancy. They found alterations in the gut microbiota composition in women who later developed GMD. This study could provide relevant insights to prevent the development of GDM. Recognition of women at high risk of GDM at an early stage of pregnancy may allow specific recommendations for the prevention of the disease simply by lifestyle modification and, in the future, by specific intervention to equilibrate the gut microbiota.