NUNZIUM

A new study led by Prof. Courtine and Dr. Jocelyne Bloch demonstrates which neurons, if activated and remodeled by electrical stimulation, allow chronic patients paralyzed by spinal injuries to stand up, walk and rebuild their muscles. The study was published on November 9 in Nature, involving scientists at the Swiss Federal Institute of Technology (EPFL), the University Hospital of Lausanne (CHUV), and the State University in Lausanne (UNIL), Switzerland. In a multi-year research program patients paralyzed by a spinal cord injury and undergoing electrical stimulation of the area that controls leg movement were able to regain some motor function. The improved motor function was shown in nine patients to last after the electrical stimulation was turned off. This suggested that the nerve fibers used for walking had reorganized. To achieve this result, the scientists relied on the understanding of how neuronal reorganization occurs. The researchers first studied the mechanisms in mice, discovering a surprising property in a family of neurons expressing a specific gene (the Vsx2 gene): while these neurons aren’t necessary for walking, they are essential for the recovery of motor function after spinal cord injury. “It is essential for neuroscientists to understand the specific role that each neuronal subpopulation plays in a complex activity like walking,” says Jocelyne Bloch. “Our new study, in which nine clinical-trial patients were able to recover some degree of motor function thanks to our implants, is giving us valuable insight into the reorganization process for spinal cord neurons.” This advancement, demonstrated in nine subjects, marks a fundamental clinical breakthrough toward the improvement of the quality of life for paralyzed patients. Hopefully, healing the paralytics may become one of the many miracles of science in a not too far future.