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News That Matters

12/11/2023 ---- 13/11/2023

A noteworthy shift is on the horizon for dementia diagnosis in the UK, thanks to a £5m project funded by the People’s Postcode Lottery and supported by Alzheimer’s Research UK and the Alzheimer’s Society. This ambitious initiative aims to develop reliable blood tests for dementia within five years, a development that could revolutionize diagnosis by making it quicker and less invasive.

Dementia, characterized by a decline in cognitive ability, affects approximately 900,000 people in the UK, with Alzheimer's disease accounting for about 60% of these cases. Projections indicate that by 2040, the number of dementia sufferers could rise to 1.4 million. The urgency for an efficient diagnostic method has been heightened by recent discoveries of medicines such as donanemab and lecanemab, which can slow cognitive decline.

Currently, dementia diagnosis relies on lengthy and often invasive processes such as mental ability tests, brain scans, or lumbar punctures, leading to wait times of up to four years for results. This delay leaves over a third of dementia patients in England without a formal diagnosis. The new project aims to address this by using a single drop of blood to confirm the presence of the disease, a development that could accelerate diagnosis and increase its reach.

Blood tests for dementia are already available in private clinics in the US and Hong Kong, costing approximately £693. The challenge lies in creating a reliable and cost-effective test suitable for use on the NHS. Several tests are currently being researched, including those identifying specific proteins such as tau and amyloid that build up in the brain a decade or more before dementia symptoms manifest.

This initiative, in collaboration with the National Institute for Health and Care Research and the UK Dementia Research Institute at University College London, has garnered interest from pharmaceutical giants Roche and Eli Lilly. Both firms have joined the race to develop a blood test for dementia, indicating growing momentum behind this project.

As part of this five-year project, the NHS Blood Biomarker Challenge aims to recruit at least 1,000 NHS patients. The goal is early detection of the condition, enabling patients to receive more support and new treatments that slow the disease’s progression. This could be a significant breakthrough, as most amyloid-lowering drug trials to date involve people with advanced disease, while these drugs might be more effective in the early stages.

However, the journey towards this innovation is not without challenges. UK regulators would need to approve any blood test, and the research must demonstrate its cost-effectiveness for NHS use. Yet, the potential benefits are substantial. Fiona Carragher, the director of research and influencing at the Alzheimer’s Society, noted that nearly four in 10 people in the UK with dementia have not received a diagnosis. A reliable and accessible blood test could help bridge this gap.

In conclusion, while Alzheimer's is not a normal part of ageing, the risk of developing the disease increases with age. The prospect of a reliable blood test for Alzheimer's within five years on the NHS represents a significant stride in combating this debilitating disease. This £5 million study, funded by the UK's leading dementia charities, could facilitate early diagnosis and pave the way for treatments that rely on early detection. The future of dementia diagnosis is on the horizon, and it holds promise for a brighter outlook.

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As the world spins on the axis of progress, the harsh consequences of global warming are becoming increasingly apparent. One of the most alarming impacts is the rapid melting of glaciers, especially in Greenland, where the pace has accelerated fivefold in the past two decades. This disturbing trend is supported by a comprehensive study of over a thousand glaciers in the region, conducted by scientists from the University of Copenhagen.

The ancient ice sheet of Greenland has the potential to cause a catastrophic 20-foot rise in sea levels if completely melted. The likelihood of this happening is growing, with glaciers now receding by an average of 25 meters per year, a stark increase from the 5-6 meters per year just two decades ago. This dramatic change was determined by analyzing 130 years of glacier development through satellite imagery and 200,000 historical photographs.

The global temperature has risen almost 1.2C above pre-industrial levels, making the prediction of 2023 being the warmest year in 125,000 years a chilling possibility. This warming trend is hastening the melting of the West Antarctic Ice Sheet, which is expected to continue this century, regardless of any reduction in global warming emissions. The melting rate could triple this century due to warmer water in the Amundsen Sea eroding the bordering ice shelves, even if global warming is limited to 1.5 degrees Celsius above pre-industrial levels.

In Nepal, the situation is equally dire. The country's mountains have lost nearly one-third of their ice over the past 30 years due to global warming, with a global temperature increase of 0.74 degrees Celsius in the last century. The melting rate of Nepalese glaciers has increased by 65% in the last decade compared to the previous one, prompting calls for an end to the "fossil fuel age".

The Alpine glaciers in Europe are also feeling the heat. Since 1850, these glaciers have seen a 60% reduction in volume, with Swiss glaciers losing half their volume between 1931 and 2016, and an additional 12% from 2016 to 2021. In the hydrological year 2022-2023 alone, 4% of glacial mass was lost. If greenhouse gas emissions persist at current levels, European glaciers, including those in Switzerland, risk almost complete melting by the end of the century.

Time is of the essence. Between 2006 and 2018, the Greenland ice sheet and glaciers contributed 17.3% and 21% respectively to the observed rise in sea levels. The race is on to prevent a climate catastrophe by limiting global temperature rise to 1.5 degrees Celsius. The melting of glaciers is not merely an environmental concern but a threat to human existence. It's crucial that we heed the call of the glaciers and take decisive action against global warming. As the adage goes, "We do not inherit the earth from our ancestors; we borrow it from our children." It's our responsibility to ensure we leave them a world worth inheriting.

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Sudan, an African nation three times the size of Israel and the Palestinian territories combined, is experiencing a major humanitarian crisis due to a brutal civil war that has taken over 10,000 lives and displaced 4.8 million people, as per the Armed Conflict Location & Event Data project. The United Nations has dubbed it the “largest child displacement crisis in the world,” with more than 3 million children displaced and 14 million children in urgent need of humanitarian assistance.

The conflict, which ignited on April 15, is chiefly between the forces loyal to army chief Abdel Fattah al-Burhan and the Rapid Support Forces (RSF), led by Mohamed Hamdan Daglo. The RSF, infamous for its ruthless tactics, recently seized El Geneina, the capital of West Darfur, a significant military victory. The war is marked by grave human rights abuses including sexual violence, torture, arbitrary killings, and the deliberate targeting of specific ethnic groups.

The United Nations has consistently urged an immediate cessation of hostilities, warning of a rise in human rights violations amid the ongoing conflict. However, these appeals have largely been ignored. The UN refugee agency (UNHCR) reported that almost 100 shelters at an internally displaced people's camp in Ardamata were destroyed, and widespread looting, including of UNHCR-supplied aid, has occurred. Thousands of individuals have been compelled to flee from a camp in El Geneina, with over 8,000 people crossing into Chad in the last week alone.

The war has not only caused massive displacement but has also severely disrupted Sudan’s healthcare system, forcing over 70 percent of the country's healthcare facilities to close. This has led to an increase in deaths from diseases such as cholera, malaria, and dengue, as well as complications during childbirth.

Moreover, the conflict has compelled many refugees to return to their home countries, often to encounter further violence. For instance, Adel Atallah, a Palestinian man, fled Gaza in 2007 due to the Israeli blockade and established a life in Sudan. However, the civil war forced Atallah and his family to return to Gaza, only to find it transformed into a war zone with Israel. This situation in Gaza has been described by the UN as an "unfolding catastrophe," with up to 10,000 people killed in the conflict.

The international community's response to the crisis has been insufficient. The UN has only received 33 percent of the $2.6 billion it needs to provide necessary humanitarian aid to Sudan. Meanwhile, other humanitarian crises, such as the potential expulsion of up to 1.7 million Afghan refugees in Pakistan, are occurring largely unnoticed.

The ongoing war in Sudan underscores the persistent suffering that can ensue when global attention wavers. The international community must not only supply the necessary humanitarian aid but also strive for a lasting peace in the region. As the conflict enters its eighth month, the people of Sudan can only yearn for an end to the violence and a return to normalcy. The international community must not let hope for Sudan be lost, as it remains a beacon for the people enduring this crisis.

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