NUNZIUM

News That Matters

24/09/2023 ---- 02/10/2023

The year 2023 was a significant milestone in the scientific community as the Nobel Prize in Physiology or Medicine was awarded to Katalin Karikó and Drew Weissman. Their pioneering work in nucleoside base modifications led to the development of effective mRNA vaccines against COVID-19, a monumental achievement in the face of a global health crisis.

Karikó, a Hungarian biochemist, and Weissman, an immunologist, embarked on their groundbreaking research in the early 1990s at the University of Pennsylvania. Their shared fascination with mRNA, the molecule that conveys genetic instructions from DNA to the cell's protein-making machinery, led them to a groundbreaking discovery. They found that dendritic cells, critical in immune surveillance, saw in vitro transcribed mRNA as foreign, triggering an inflammatory response. This response was nearly eradicated when base modifications were introduced into the mRNA, a revelation that reshaped our understanding of cellular recognition and response to different mRNA forms.

Their research, published in 2005, laid the groundwork for mRNA vaccines. Over the next years, they demonstrated that base-modified mRNA enhanced protein production significantly compared to unmodified mRNA. Initially overlooked, these findings became a cornerstone in the battle against the COVID-19 pandemic.

By 2020, the world was grappling with the pandemic and desperate for a vaccine. Drawing on Karikó and Weissman's work, two base-modified mRNA vaccines encoding the SARS-CoV-2 surface protein were swiftly developed and approved by December 2020. These vaccines, manufactured by Pfizer/BioNTech and Moderna, have been administered over 13 billion times globally, saving millions of lives and preventing severe disease in countless others.

Despite their monumental achievement, both Karikó and Weissman continue their careers in science. Karikó is a Professor at Szeged University in Hungary and an Adjunct Professor at the Perelman School of Medicine at the University of Pennsylvania. Weissman serves as the Roberts Family Professor in Vaccine Research and Director of the Penn Institute for RNA Innovations.

Their innovative work has not only been crucial in curbing COVID-19 but has also opened new avenues in medicine. The mRNA technology they developed is being examined for potential use against other diseases, including malaria, RSV, HIV, and cancer.

In 2023, the Nobel Prize committee recognized their revolutionary contribution by awarding them the Nobel Prize in Physiology or Medicine. Their work has reshaped our understanding of mRNA's interaction with our immune system, leading to an unprecedented rate of vaccine development during the COVID-19 pandemic.

In summary, Katalin Karikó and Drew Weissman's story epitomizes the power of scientific curiosity and perseverance. Their pioneering work has not only changed the world but also saved countless lives. Their story continues to inspire future scientists and offers a beacon of hope amidst global health crises.

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The political landscape of Slovakia is undergoing a significant transformation as former Prime Minister Robert Fico initiates negotiations to form a coalition government. Fico's Smer-SD party, founded in 1999, secured nearly 23% of the votes in the recent elections, paving the way for his possible fourth term. Born on 15 September 1964, Fico, a former Communist party member, has emerged as a key player in Slovak politics, notably leading the country into the eurozone in 2009.

Fico's political career, however, has been marred by controversy. Despite his election victory in 2010, he failed to form a coalition and resigned in 2018 amidst protests over a journalist's murder. Fico's admiration for Putin and Hungary's leader, Viktor Orban, his resistance to aiding Ukraine against Russia, and criticism of sanctions against Moscow have drawn attention. His views on immigration, same-sex marriage, adoption, and his opposition to Covid pandemic measures such as masks, lockdowns, and vaccination have also been contentious.

As Fico begins coalition talks, political analysts anticipate he will seek alliances with the moderate Hlas and the nationalist, pro-Russian Slovak National party (SNS). This potential coalition could command a slim majority of 79 seats in the 150-seat Slovak parliament. Nevertheless, observers caution about potential threats to the rule of law, the judiciary, media, and minority rights under this coalition.

Fico's potential return to power could also influence Slovakia's foreign policy. The country's arms shipments to Ukraine might decelerate or halt entirely, and Slovakia may align more closely with Hungary's Viktor Orban, thereby challenging the EU’s consensus on military support for Kyiv, migration, and the green transition.

The election results have stirred diverse reactions. Progressive Slovakia (PS), a liberal and pro-Ukrainian party that secured 18% of the vote, has pledged to do everything possible to prevent Fico from governing. Slovakia's President, Zuzana Čaputová, who has tasked Fico with forming a government, has responded with restrained enthusiasm to his victory.

Fico's victory has also caused unease among European Union and NATO members due to his stance on Ukraine and his criticism of the EU and NATO. As a member of both NATO and the European Union, Slovakia has traditionally backed Ukraine and called for strong EU sanctions against Russia, a position that may shift under a Smer-SD-led government.

However, not all outlooks are bleak. Some analysts suggest that Fico may steer clear of damaging disputes with Slovakia's main EU and NATO partners, given the probable participation of the more moderate Hlas in the coalition.

With Fico's coalition negotiations underway, the future of Slovakia's political landscape is at a critical juncture. The outcomes of these discussions could have far-reaching implications for not only Slovakia but the entire European Union. Whether Fico will guide Slovakia towards a more nationalist, anti-western direction or strike a balance between pro-EU positions and his own rhetoric is yet to be determined. What is certain is that Slovakia's political future is embarking on a crucial new chapter.

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