NUNZIUM

News That Matters

17/08/2023 ---- 18/08/2023

Nestled within Indonesia's boundaries is Wallacea, a unique region of approximately 338,000 square kilometers named after British naturalist Alfred Russel Wallace. Home to the world's most diverse and distinctive species like the Komodo dragon and the purple-bearded bee-eater, this region is a living testament to Earth's evolutionary history. However, as we approach Wallace's 200th birth anniversary in 2023, Wallacea's rich biodiversity faces significant threats from human activities.

Over the past forty years, Wallacea's lush ecosystems, from its verdant forests to its vibrant reefs, have been under increasing pressure from mining, agriculture, and infrastructure development. Between 2000 and 2017, Sulawesi, one of the region's primary islands, lost approximately 10.89% of its forests, equivalent to an alarming 2.07 million hectares. West Sulawesi and Southeast Sulawesi were the most affected, with forest cover losses of 13.41% and 13.37% respectively.

This deforestation is largely attributed to companies clearing land for palm oil, cocoa, and chocolate plantations, particularly over the last decade. Furthermore, the region's soil houses the world's largest nickel reserve, a crucial element in electric vehicle batteries, exacerbating the deforestation issue due to mining activities.

However, the damage extends beyond terrestrial ecosystems. Wallacea's reefs, globally renowned for their diversity and beauty, have experienced severe damage from overfishing and destructive practices. These reefs not only attract tourists but also play a crucial role in the local economy, making their degradation a significant concern for local communities.

The region's avian and primate populations are also in decline due to deforestation, with bird species diversity dwindling and monkey and tarsier populations nearing extinction. Despite the grim scenario, hope persists.

In mid-August 2023, the Wallacea Science Symposium is set to occur in Makassar, South Sulawesi Province. This event aims to spotlight the region's distinctiveness and foster strategic planning for sustainable development. It calls upon various stakeholders, including the Indonesian government, scientists, mining and plantation companies, tourism industries, and local communities, to collaborate for Wallacea's future.

However, the responsibility extends beyond these stakeholders. Everyone can contribute to conservation efforts - from donating to organizations working to protect the region, reducing our carbon footprints through renewable energy and reduced fossil fuel use, to supporting sustainable tourism.

As we approach the bicentennial of Alfred Russel Wallace, the naturalist who illuminated Wallacea's unique biodiversity to the world, it's crucial to remember that our efforts are not only about preserving the past. They are centered on ensuring a future where Wallacea's unique species continue to thrive, and a rich, diverse, and vibrant Wallacea can be passed on to future generations.

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A significant leap forward in xenotransplantation has been made by surgeons at the New York University Langone Transplant Institute in the United States. For the first time ever, a pig kidney has been successfully transplanted into a human body and functioned normally for over a month. This medical milestone represents the longest a pig kidney has ever functioned in a human body.

The unique opportunity for this revolutionary procedure was presented when the family of Maurice "Mo" Miller, a 57-year-old man who passed away suddenly, generously donated his body for scientific use. The pig kidney used in the transplant was genetically modified to eliminate a gene that produces biomolecules usually attacked and rejected by the human immune system. This innovative approach has addressed the long-standing issue of immune system rejection in xenotransplantation, the process of transplanting organs from animals to humans.

This medical breakthrough brings hope to the over 103,000 people in the US currently awaiting organ transplants, of which 88,000 are in need of kidneys. Thousands lose their lives each year while on the waiting list, and the successful use of genetically modified pig organs could significantly decrease this number. The potential of xenotransplantation is such that the US Food and Drug Administration (FDA) is considering permitting small, selective studies of pig heart and kidney transplants in volunteer patients.

This achievement follows a similar success by the University of Alabama at Birmingham, which reported a successful transplantation of a pair of pig kidneys into a donated body, functioning without issue for seven days. However, challenges and uncertainties remain in the field of xenotransplantation. Last year, a gene-edited pig heart transplant performed by surgeons at the University of Maryland resulted in the recipient surviving only two months before the organ failed. The reactions of a live patient to a pig organ and the longevity of such experiments remain unclear and reliant on the stability of the donated body.

The successful operation involved doctors Adam Griesemer and Jeffrey Stern traveling hundreds of miles to retrieve kidneys from genetically modified pigs housed by Revivicor Inc., a Virginia-based company. The pig's thymus was attached to the transplanted kidney to increase human tolerance of the organ, and the team used standard immune-suppressing drugs employed in current transplant procedures.

In conclusion, xenotransplantation stands on the threshold of a new era. The successful transplantation of a pig kidney into a human body, functioning for over a month, is a beacon of hope for those awaiting organ transplants. As the potential to save lives using animal organs becomes more tangible, a new wave of optimism washes over the medical community and beyond.

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