NUNZIUM

News That Matters

07/06/2023 ---- 16/06/2023

Researchers led by Andrew Macadam at the UK's National Institute for Biological Standards and Control have developed a "super-engineered" vaccine to combat vaccine-derived polio strains. This groundbreaking vaccine has shown promising results in initial tests and is now undergoing human trials. Since 1988, global efforts have eradicated two of the three poliovirus subtypes, with only 21 cases of wild polio reported in the past year. However, there have been 665 cases of vaccine-derived polio across 23 countries, primarily in sub-Saharan Africa.

The Covid-19 pandemic and conflicts in polio-vulnerable countries have contributed to the rise in cases. The new vaccines use genetic engineering to lower the risk of the attenuated virus reverting to a virulent state. Over 650 million children in 30 countries have received the nOPV2 vaccine since March 2021. However, nOPV2 has regained virulence four times, highlighting the need for comprehensive public health initiatives. The global polio management is transitioning from the Global Polio Eradication Initiative to national immunisation and disease-surveillance programmes, with the World Health Organisation enacting a country-specific approach.

The "super-engineered" polio vaccines aim to prevent the virus from mutating into dangerous forms that can cause outbreaks and paralysis. Oral vaccines contain weakened live polio viruses, and the genetic redesign locks them into that weakened state. US and UK teams have developed upgraded vaccines against all three types of polio. Researchers have genetically altered the weakened virus to make it much harder for it to cause paralysis, resulting in a vaccine that is 50 to 100 times more stable.

In March 2021, the World Health Organization made the researchers' vaccine against type-two polio available for emergency use, and it has since been used more than 650 million times. Researchers have now detailed the creation of stable vaccines against polio types one and three in the journal Nature. First-stage human trials of the upgraded vaccines have been conducted, with "very promising" data. These are the first new polio vaccines in 50 years.

Eradicating polio requires reaching every child with vaccines, which has been a challenge in some of the poorest and most conflict-ridden parts of the world. More stable vaccines are a "significant part" of the plan for a polio-free world, but vaccination coverage is crucial. Vaccine-derived polio outbreaks are causing problems in places facing complex humanitarian emergencies, such as the Democratic Republic of Congo and Yemen. Oral polio vaccines are no longer used in the UK and other countries with established healthcare systems, which have moved to the polio injection.

In conclusion, the development of the "super-engineered" polio vaccine is a significant milestone in the fight against polio. These genetically altered vaccines offer a more stable and effective solution to combat vaccine-derived polio strains. However, the success of these vaccines relies on reaching every child in the most vulnerable regions of the world. With continued global efforts and collaboration, a polio-free world may soon become a reality.

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This week marked a significant turning point in the Russia-Ukraine war, with diplomatic and military developments leading to a stronger international support for Ukraine. UK Prime Minister Rishi Sunak visited the White House to unveil a new economic partnership with President Joe Biden, focusing on investment links, supply chain resilience, and AI development. Sunak's visit improved coordination on Ukraine and resolved the Northern Ireland trade dispute.

French President Emmanuel Macron hosted German Chancellor Olaf Scholz and Polish President Andrzej Duda to discuss military support for Kyiv's counteroffensive and humanitarian aid following the Kakhovka dam breach. France has intensified the delivery of ammunition, weapons, and armored vehicles to Ukraine, while Poland and other former Soviet states have been brought closer to the EU and NATO through the Weimar Triangle meetings.

Ukraine reported its first gains in the counteroffensive, reclaiming territory from Russia using Western weapons. Despite contradictory reports from Kyiv and Moscow, analysts believe Ukraine has made recent advances near Velyka Novosilka. In response, Russia claimed to have repelled Ukrainian attacks around several villages in southeast Ukraine.

The US announced a $325 million military aid package for Ukraine, and the EU pledged an additional €100 million in loans for war damage repair. The Kakhovka dam disaster death toll rose to 10, with 41 people still missing, and the UN's nuclear chief's visit to the Russian-held Zaporizhzia nuclear power plant was delayed for safety reasons.

In conclusion, this week witnessed a turning point in the Russia-Ukraine war, with allies uniting and Ukraine striking back. The international community's support for Ukraine has never been stronger, and the situation remains fluid as diplomatic efforts and military aid from the US, UK, France, Germany, and Poland continue to bolster Ukraine's counteroffensive.

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The world is experiencing a sizzling summer with high temperatures, El Niño events, and cyclone threats. China's crucial flood control facility, the Three Gorges Dam, saw its water level drop to 151.9 meters on June 6, 2023, while northern China is expected to face temperatures above 35°C in the next three days. Frequent rainfall and possible heavy rainstorms are also expected along the Yangtze River. High temperatures are arriving earlier and increasing in number of days in most of China, as well as in India, Vietnam, and Singapore, with some breaking historical records.

Spring 2023 had higher-than-average national temperatures in China, ranking seventh highest in history, and precipitation has been generally less than average. The World Meteorological Organization (WMO) reports a 98% chance that at least one of the next five years will be the hottest on record. Guangdong has issued high-temperature subsidies to workers, and Jiangsu Province's daily power load has exceeded 100 million kilowatts, prompting State Grid Jiangsu Electric Co to launch an "electricity calendar" function for users to save electricity during peak periods.

The climate-changing trend will become more obvious unless energy usage shifts to green energy, according to Lin Boqiang, director of the China Center for Energy Economics Research at Xiamen University. The Global Climate Status Report 2022 by WMO states that 2015-2022 was the warmest eight years on record, with glacial melt and sea-level rises reaching record levels in 2022. An El Niño event has started in the Pacific Ocean, likely to make 2024 the world's hottest year and potentially pushing global warming past the key 1.5°C milestone. This phenomenon affects world weather, causing drought in Australia, increased rain in southern US, and a weakened Indian monsoon. The El Niño event is expected to last until next spring.

US scientists confirmed El Niño conditions in May, with an 84% chance of exceeding moderate strength by the end of the year. Global temperatures are currently around 1.1°C above the 1850-1900 average, and the El Niño event could add up to 0.2°C to global temperatures. Researchers say a temporary breach of the 1.5°C limit is likely in the next few years. The El Nino phenomenon has arrived, according to the US National Oceanic and Atmospheric Administration (NOAA), last occurring from 2018 to 2019. It can cause heavy rainfall, droughts, and temperature records in certain locations, with climate change exacerbating or mitigating its impacts.

Increased rainfall is expected in southern South America, central Asia, and the Horn of Africa, while there is an increased risk of droughts in Australia, Indonesia, and parts of southern Asia. Australia has been warned of warmer, drier days and increased wildfire vulnerability. Japan partly blamed El Niño for its warmest spring on record. The phenomenon suppresses hurricane activity in the Atlantic and boosts typhoon activity in the central and eastern Pacific.

Tens of thousands have been evacuated in India and Pakistan due to Cyclone Biparjoy, with over 40,000 people leaving their homes as the cyclone approaches. The cyclone is expected to make landfall as a "very severe cyclonic storm," with gales up to 150 km/h (93 mph) predicted for coastlines. Rains and storms ahead of the cyclone have already killed seven people in Gujarat and Maharashtra. Scientists warn that the intensity of tropical cyclones will increase due to climate change, making preparations more vital than ever. Addressing the root causes of climate change and working towards a more sustainable future is crucial as the world faces the consequences of a sizzling summer.

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NATO's largest air defense exercise since its formation in 1949, Air Defender 23, is set to take place from June 12 to 23, involving over 10,000 soldiers from 25 countries and more than 100 aircraft, including F-35 stealth combat aircraft from the US. Germany will host the exercise and serve as the logistical hub, with three flight zones in the country temporarily closed to civilian air traffic. The drills will include evacuation from an airfield, supporting ground troops, airborne battles, and interception of medium-range missiles, while the North Sea will see defensive drills against enemy submarines or ships. This show of force comes at a time of heightened tensions with Russia, particularly due to the ongoing crisis in Ukraine.

The situation in Ukraine has worsened, with thousands of Ukrainians fleeing the city of Kherson and downstream areas due to rising flood waters from the Kakhovka dam breach. Accusations are flying between Ukrainian and Russian authorities over responsibility for the disaster, which has left at least 16,000 people homeless and thousands more at risk of flooding. The United Nations and Amnesty International have called the situation a "huge humanitarian disaster," with long-term consequences predicted for agriculture in the region and global wheat prices.

The Ukrainian army has launched an offensive to break through Russian defenses, with the Institute for the Study of War (ISW) believing that a Ukrainian counter-offensive has begun, aiming to push back Russian forces and reclaim occupied territories. The Zaporizhzhia Nuclear Power Plant, Europe's largest nuclear facility, is under threat due to catastrophic flooding from the Kakhovka dam collapse. The plant's last operating reactor has been put into cold shutdown as a safety precaution, although the Ukrainian nuclear energy agency Energoatom has stated that there is "no direct threat" to the plant due to the dam breach. However, shelling near the site and damaged overhead lines connecting the plant to Ukraine's energy system have raised concerns.

International Atomic Energy Agency head Rafael Mariano Grossi is set to visit Kyiv next week to discuss a new program to help avoid nuclear disaster. At the same time, Ukrainian authorities report at least four civilian deaths in Russian strikes using Iranian-made Shahed drones, missiles, and artillery, further intensifying the conflict. As the crisis in Ukraine unfolds, NATO's Air Defender 23 exercise serves as a powerful reminder of the alliance's commitment to maintaining peace and stability in the region, with participating countries standing united and ready to face any challenge.

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The ongoing conflict between the Sudanese Armed Forces, led by General Abdel Fattah Burhan, and the Rapid Support Forces (RSF) paramilitary group, led by General Mohammed Hamdan Dagalo (Hemeti), has resulted in over 1,000 deaths in the capital city, Khartoum, and the Darfur region. Despite ceasefires, fighting continues, forcing residents to conduct amateur burials in unconventional locations, potentially destroying evidence of war crimes and spreading disease.

Health authorities are collaborating with the Red Cross and the Sudanese Red Crescent to move bodies to cemeteries, but ongoing violence hinders their efforts. A war crimes tribunal seems remote amidst the current chaos. A 24-hour ceasefire on June 11 allowed civilians to stock up on supplies or flee the area.

The conflict has led to over 1,800 deaths and nearly two million displaced people, according to the NGO Armed Conflict Location and Event Data Project and UN data. Egypt has reversed its visa exemption for certain Sudanese nationals, citing a crackdown on "illegal activities."

Sudan faces a potential famine due to the conflict, with Muzan Alneel of the ISTiNAD research center highlighting the rapidly decreasing resources and lack of crops. The Sudanese economy is near collapse, with high inflation, a collapsed financial system, and a lack of essential resources. The Health Ministry reports around 800 deaths and at least 6,000 injured, but the real numbers are likely higher.

Theodore Murphy of the European Council on Foreign Relations and Hager Ali of the German Institute for Global and Area Studies emphasize the importance of support in resolving the conflict. Ethnic differences in the Darfur region are fueling the violence, similar to the conflict in 2003-2005. The UN's Office for the Coordination of Humanitarian Affairs confirms reports of arbitrary killings, looting, and rape. As the struggle for power continues, the people of Sudan face an uncertain future, with the threat of famine, disease, and ongoing violence casting a dark shadow over the nation.

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Former President Donald Trump has been indicted on seven counts concerning his handling of classified documents after leaving the White House in 2021. The charges include obstruction of justice, destruction or falsification of records, conspiracy, false statements, and a charge under the Espionage Act. This is the second time Trump has faced criminal charges this year, following an April indictment by the Manhattan district attorney. The indictment comes amidst Trump's 2024 presidential campaign and ongoing criminal charges in two jurisdictions.

Attorney General Merrick Garland appointed Special Counsel Jack Smith seven months ago to investigate Trump's handling of classified documents at his Mar-a-Lago resort. Since the investigation began in August, 11,000 documents have been seized from Trump's Florida property, with around 100 classified or top-secret. Trump is scheduled to appear at the Federal Courthouse in Miami on Tuesday, with the US Secret Service and US Marshals not receiving advance notice of the indictment.

Trump's congressional allies have defended him on social media, and his aides and advisers are reportedly prepared to fight back. However, some close to Trump are concerned about the indictment's long-term impact. Democrats emphasize that no one is above the rule of law.

Trump responded to the indictment on his Truth Social platform, proclaiming his innocence and accusing the Department of Justice of using "warfare" to halt his 2024 candidacy. Georgetown University Law Center professor David Super believes the indictments will not hinder Trump's ability to run for office. The trial will take place in Florida, a state that supported Trump in the 2016 and 2020 elections. Trump's lawyer, James Trusty, has disclosed the likely charges, and Trump is currently staying at his Bedminster, New Jersey golf resort.

Two additional investigations into Trump's conduct are ongoing, including a separate inquiry into his alleged role in the January 6 Capitol riot, also overseen by Jack Smith. The Justice Department has not commented or confirmed the announcement made on Trump's Truth Social platform regarding the indictment.

This marks the first time a former president has been indicted on criminal charges, with former federal prosecutor Joe Moreno calling the situation "embarrassing." The charges relate to the violation of federal laws, including "gathering, transmitting or losing defense information" under the Espionage Act.

In summary, the indictment of Trump on seven counts related to his handling of classified documents adds another dimension to his 2024 presidential campaign. While the trial's outcome is uncertain, the case will continue to generate headlines and fuel intense debate across the political spectrum.

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Insomnia may be a silent threat to your health, particularly if you're under 50 years old, as it has been linked to an increased risk of stroke. A recent nine-year study conducted by Wendemi Sawadogo, an epidemiologist and researcher at Virginia Commonwealth University in Richmond, followed over 31,000 people with no history of stroke and found a significant association between insomnia and stroke risk.

The study revealed that those with five to eight symptoms of insomnia had a 51% increased risk of stroke compared to those without insomnia, while those with one to four symptoms had a 16% increased risk. In April, another study reported that people who slept less than five hours a night were three times more likely to have a stroke than those who got seven hours of sleep. Sleeping more than nine hours increased stroke risk twofold, while sleep apnea was associated with a threefold increase in stroke risk. Snoring increased the risk by 91%, snorting by almost three times, and napping for over an hour increased stroke risk by 88%.

Dr. Phyllis Zee, director of the Center for Circadian and Sleep Medicine at Northwestern University’s Feinberg School of Medicine in Chicago, explains that poor sleep can disrupt the body's ability to regulate metabolism, blood pressure, and inflammation, all risk factors for stroke. Good sleep hygiene, a healthy diet, and regular exercise can reduce the negative impact of sleep disorders and decrease stroke and cardiovascular disease risk.

The link between insomnia and stroke risk is stronger in participants under 50, with nearly four times the risk of having a stroke. The findings were published in the journal Neurology. The research involved over 31,000 participants with an average age of 61 and no history of stroke, followed for an average of nine years. Participants were asked about their sleep quality, with scores ranging from zero to eight (higher numbers indicating more severe symptoms).

Researchers adjusted for factors affecting stroke risk, such as alcohol use, smoking, and physical activity level. Of the 2,101 cases of stroke, 1,300 had one to four symptoms, 436 had five to eight symptoms, and 365 had no symptoms. Participants under 50 with five to eight symptoms had nearly four times the risk of stroke compared to those with no symptoms, while people aged 50 or older with the same number of symptoms had a 38% increased risk of stroke compared to those without symptoms.

The association was greater for people with diabetes, high blood pressure, heart disease, and depression. Managing insomnia symptoms at a younger age may be an effective strategy for stroke prevention. Future research should explore stroke risk reduction through management of sleeping problems.

The INTERSTROKE study, an international case-control study of patients with first acute stroke and matched controls, also found sleep disturbance symptoms associated with increased odds of acute stroke. Sleep disturbance symptoms may be a marker of increased individual risk or represent independent risk factors. Sleep interventions in stroke prevention need further investigation in clinical trials.

In conclusion, taking steps to improve your sleep hygiene, maintain a healthy diet, and exercise regularly can help reduce the risk of stroke and other serious medical conditions. Don't let insomnia steal your sleep and your health – take action today!

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