NUNZIUM

News That Matters

07/05/2023 ---- 09/05/2023

Eli Lilly's experimental drug donanemab has demonstrated positive results in slowing cognitive and functional decline in early-stage Alzheimer's patients, marking a significant breakthrough in the treatment of the disease. The TRAILBLAZER-ALZ 2 Phase 3 study revealed that donanemab slowed decline by 35% over 18 months using the integrated Alzheimer's Disease Rating Scale (iADRS) measure. The company aims to file for FDA approval by the end of June, with potential approval by H1 2023.

Alzheimer's disease affects over 6 million Americans, with an estimated 1.7 million to 2 million people over 65 in early stages. Drug development for Alzheimer's has seen numerous failures, but Lilly's drug is among a new group, including Eisai and Biogen's Leqembi, which received accelerated FDA approval in January, showing promise in treatment.

Donanemab works by removing amyloid plaque buildups in the brain, believed to be responsible for Alzheimer's progression. Administered by infusion once a month, 52% of trial patients were able to stop taking the medicine by one year, and 72% by a year and a half. Researchers observed a 35% slowing in cognitive and functional decline in the group with intermediate levels of tau, a brain protein. When combined with the group with higher levels of tau, the figure was 22%.

The late-stage trial, involving 1,182 participants, showed that 50% of patients who received donanemab experienced no worsening of Alzheimer's symptoms after a year, while 71% of patients on placebo saw disease progression. However, side effects include brain swelling or abnormalities, with at least two deaths linked. More data is needed to determine if donanemab is truly different from Leqembi in terms of benefits and risks.

Leqembi is not currently covered by Medicare, but full FDA approval could change this as early as July. The potential pricing for donanemab has not been discussed before approval. If approved, donanemab could generate $7.5 billion a year for Lilly at its peak.

Eli Lilly's Q1 revenue dropped 11% due to declining sales of its coronavirus antibody treatment. However, the success of donanemab could mark a turning point for the company and bring hope to millions of Alzheimer's patients worldwide. The full results of the TRAILBLAZER-ALZ 2 study will be presented at the Alzheimer's Association International Conference in July, providing further insight into this promising new treatment option.

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China's Chang'e-5 mission has led to a groundbreaking discovery in lunar soil samples, unveiling the potential for revolutionizing future lunar base construction. Researchers from the Institute of Physics at the Chinese Academy of Sciences have found natural fiberglass, a first of its kind, in the samples collected on May, 2023. This glass material is formed from lunar soil's excellent molding properties and comes in various types, such as spherical, ellipsoidal, and dumbbell-shaped glass beads, colloidal items with porous structure, and sputtering material in fluid form. The origin of these glass materials is believed to be the result of mineral melting and rapid cooling due to frequent meteorite impacts on the lunar surface.

This discovery is important for understanding the formation and evolution of lunar soil, as well as recording multi-scale meteorite impacts. Different shapes of the glass materials reflect the impact intensity of meteorites, according to Zhao Rui, a researcher from the Institute of Physics. Natural fiberglass, for instance, has a higher length-to-diameter ratio and is formed under lower temperature and speed during meteorite impacts, while glass beads have a lower length-to-diameter ratio, reflecting more intense meteorite impacts.

In the meantime China's Shenzhou-14 spaceship, launched on June 5, 2022, landed at Jiuquan Satellite Launch Center after 276 days in orbit, marking a milestone in China's efforts to develop a fully reusable space transportation system. Although Chinese authorities have not disclosed details or images of the craft, it has been compared to the US Air Force's X-37B autonomous Boeing space plane. Space expert Song Zhongping believes that the maturing reusable spacecraft technology will reduce costs and allow for more complicated missions, with the Long March-2F carrier rocket potentially being used in future manned missions.

With a payload launching capability similar to the X-37B, weighing around 8 tons, the latest test was the longest, most complicated, and most challenging, surpassing the US' X-37B's 224 days in orbit. Health monitoring of the power system and service life assessment have been listed as major scientific problems for 2023 space development. The reusable spacecraft can land horizontally, making it safer for the crew and opening up possibilities for applications in suborbital or space tourism and fast point-to-point transportation.

The discovery of natural fiberglass in lunar soil samples presents an exciting opportunity for future lunar base construction, while China's advancements in reusable spacecraft technology pave the way for more efficient and cost-effective space missions. These findings underscore the importance of international collaboration and the sharing of knowledge for the betterment of humankind.

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The deadliest Israeli airstrike since August 2021 has resulted in 13 Palestinian casualties, including three Islamic Jihad commanders, eight women, and children, with 20 people injured. Israel launched this operation targeting militants posing an imminent threat to its citizens, prompting the Islamic Jihad to vow revenge and Israel to prepare for days of fighting. Early Tuesday morning, 40 Israeli warplanes and helicopters attacked across Gaza, killing four children and four women, among others.

The Israel Defense Forces (IDF) struck ten sites used for weapon manufacturing and six Islamic Jihad military facilities. Hamas leader Ismail Haniyeh warned that assassinating leaders would only lead to more resistance. The Palestinian Islamic Jihad (PIJ) is the largest militant group in Gaza next to Hamas and is responsible for many rocket attacks on Israel.

Tensions between Jewish and Muslim worshippers escalated at the Al-Aqsa Mosque compound in Jerusalem on April 9, 2023, when thousands of Jewish worshippers gathered at the Western Wall for Passover, while Palestinians performed prayers for Ramadan. Palestinians protested the presence of Jewish visitors at the Al-Aqsa compound, fearing Israeli intentions to take over the site. The situation escalated after an Israeli police raid on the mosque, leading to violence and rocket fire from Palestinian militants.

In response, Israeli airstrikes targeted the Gaza Strip and southern Lebanon. Hezbollah's chief, Hassan Nasrallah, met with Hamas leader Ismail Haniyeh to discuss developments and escalating resistance. Militants in Syria fired rockets towards Israel and the Golan Heights, with Israel responding with artillery fire and airstrikes on Syrian army sites. Turkish President Recep Tayyip Erdogan called for an end to hostilities in a phone call with Israeli counterpart Isaac Herzog.

Over the weekend, three people were killed in Palestinian attacks in Israel and the occupied West Bank. Israel conducted airstrikes in Gaza after Palestinian factions fired rockets across the border following Khader Adnan's death. Adnan, a political leader within the Islamic Jihad, died after an 87-day hunger strike in Israeli custody, which Palestinian leaders described as an assassination.

Israeli Prime Minister Benjamin Netanyahu met with security officials to assess the situation. Mustafa Barghouti, general secretary of the Palestinian National Initiative (PNI), called Adnan's death an "ugly assassination." The number of Palestinian administrative detainees has risen to over 1,000 in the past year, the highest number in two decades. Israeli rights group B'Tselem described Adnan's hunger strike as a non-violent protest against the injustices of the occupation.

In recent weeks, tensions between Israelis and Palestinians have soared, with rocket attacks from Gaza and Lebanon and Israeli airstrikes in response. Jewish-Muslim tensions at the Al-Aqsa Mosque have further fueled the conflict, with thousands of Jewish worshippers gathering at the Western Wall for Passover and Palestinians performing prayers for Ramadan.

As the situation continues to escalate, international leaders call for an end to hostilities and a peaceful resolution. However, with the ongoing rocket attacks, airstrikes, and tensions surrounding the Al-Aqsa Mosque, the path to peace remains uncertain.

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Sudan's ongoing unrest, resulting from a power struggle between the Sudanese Army led by Gen. Abdel-Fattah Burhan and the Rapid Support Forces (RSF) under Gen. Mohamed Hamdan Dagalo, has led to a devastating humanitarian crisis and potential regional spillover. Since April 15, at least 700 lives have been lost, with 479 reported as civilians by the Sudanese doctors' union. The United Nations warns of a deepening crisis with the potential for famine, as hundreds of thousands have been displaced.

Despite multiple truce deals declared and violated, fighting continues in the capital, Khartoum. Ceasefire talks are underway in Jeddah, Saudi Arabia, with support from Saudi Arabia and the United States. However, both the army and RSF continue to seek military advantage on the ground. US intelligence chief Avril Haines warns of a protracted conflict with potential regional spillover challenges.

The conflict has forced refugees to flee Sudan, crossing into Ethiopia, Chad, and South Sudan, with Chad facing the threat of instability. The crisis disrupts plans for a transition to civilian rule in Sudan and raises concerns about shared Nile waters, oil pipelines, and potential humanitarian crises. Egypt and Sudan are worried about threats to their water supplies from the Grand Ethiopian Renaissance Dam on the Blue Nile. Sudanese mercenaries and militia fighters have been active in Libya's conflict, contributing to tensions in Sudan's Darfur region. Gulf Arab states, Saudi Arabia, and the United Arab Emirates, which have investments in Sudan, seek to stabilize the region. South Sudan's oil output is exported via a pipeline through Sudan, and the fighting has hampered logistics and transport links.

The crisis highlights the limitations of neighboring countries in mediating and the potential impact on negotiations over the controversial Grand Ethiopian Renaissance Dam. The US, UN, and the Intergovernmental Authority on Development (IGAD) have called for an immediate ceasefire and warn of potential risks to the Horn of Africa region.

The Sudanese army has expressed willingness to extend the ceasefire for 72 hours, with General Abdel Fattah al-Burhan approving a plan to extend the truce and send an envoy to South Sudan's capital, Juba, for talks. Presidents of South Sudan, Kenya, and Djibouti are working on a proposal to extend the truce and hold talks between forces.

The international community must act swiftly and decisively to end the violence and support the Sudanese people in their quest for peace, stability, and democracy. The stakes are high for Sudan and its neighbors, with potential regional destabilization and the involvement of foreign powers.

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Envision a world where robots can engage in advanced conversations, learn complex tasks, and work tirelessly without breaks or pay. This once far-fetched dream is now becoming a reality, thanks to rapid advancements in artificial intelligence and robotics. Companies like OpenAI, Tesla, Boston Dynamics, and Figure are leading the charge in creating humanoid robots that could revolutionize various industries, including manufacturing, construction, and healthcare.

OpenAI, creator of the popular AI program ChatGPT, recently invested $23 million in Norwegian company 1X, formerly Halodi Robotics. Collaboratively, they plan to develop a humanoid worker robot called Neo, equipped with OpenAI's ChatGPT artificial intelligence. This advanced AI system will enable the robot to engage in real conversations and perform complex tasks, making it a valuable addition to the workforce.

Other companies are also developing humanoid robots. Boston Dynamics is focusing on robots with hands, Elon Musk believes his Optimus robot will generate more revenue than Tesla car sales, and Hanson Robotics and Engineered Arts are working on robots that can mimic facial expressions and engage in human-like conversations.

These AI-powered humanoid robots have the potential to be stronger and more efficient than humans, working 24/7 without getting tired or requiring pay. According to Goldman Sachs Research, the market for humanoid robots could reach $6 billion in the next 10-15 years, potentially filling 4% of the projected US manufacturing labor shortage by 2030 and 2% of global elderly care demand by 2035. In an upside scenario, the market could grow up to $154 billion by 2035.

Humanoid robots will rely on neural networks to understand and replicate human movements, learning complex tasks by observing humans through motion capture systems. This swarm-based learning capability, combined with advanced communication abilities, will make these robots a formidable presence in the workforce.

However, the rise of AI-controlled humanoid robots raises concerns about job security and ethical considerations. As robots become more capable of performing tasks traditionally done by humans, job displacement becomes increasingly relevant. Additionally, ethical considerations must be addressed, such as responsibility towards AI systems, their ethical development, and the potential consequences of widespread adoption.

Despite these concerns, the development of AI-powered humanoid robots continues to progress. Bernt Øyvind Børnich, CEO and founder of 1X Technologies, is excited about OpenAI's funding and the shared mission to create advanced humanoid robots. With the backing of major companies like OpenAI and Tesla, the future of humanoid robots in the workforce is increasingly promising.

As we stand on the cusp of a new era in robotics and artificial intelligence, it is crucial to consider both the benefits and challenges that AI-powered humanoid robots present. While they hold the potential to revolutionize industries and boost productivity, their impact on job security and ethical considerations must not be overlooked. The development and integration of these advanced robots into our society will undoubtedly shape the future of the workforce in ways we have yet to fully comprehend.

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The World Health Organization (WHO) has declared that COVID-19 is no longer a global emergency, marking a symbolic end to the pandemic. Despite this, the virus remains a global health threat, with some regions experiencing spikes in cases. The decision means that COVID-19 will be treated like a common disease such as influenza, and emergency response measures can be lifted. However, the production, approval, and emergency use of vaccines will follow normal procedures, which may now take longer. The WHO's decision is based on the current stable situation, low global prevalence, decreasing pathogenicity, and strong population immunity due to vaccinations and infections. Experts warn that the virus will continue to be present, and surveillance and research will persist.

Since the pandemic's onset in early 2020, an estimated 20 million people have died from COVID-19, with 6.9 million deaths occurring after the public health emergency declaration on January 30, 2020. The virus has caused disruptions and devastation worldwide, with the United States being one of the hardest-hit countries. The virus still poses a significant threat, claiming a life every three seconds.

Countries are urged to transition to a new phase of managing the virus like other infectious diseases, maintaining surveillance and response systems and being prepared to reinstate health emergency declarations if needed. WHO Director-General Tedros Ghebreyesus has set up a Review Committee for long-term COVID-19 management recommendations, emphasizing that the fight against the virus is not over.

As the world adjusts to this new phase, changes in pandemic response measures are expected. In the United States, President Joe Biden plans to end the national coronavirus emergency on May 11. This will lead to changes in COVID-19 data tracking, with the CDC no longer tracking community levels and states no longer required to report cases. Hospital admissions data will be relied upon instead, with hospitals reporting weekly instead of daily. Wastewater surveillance will continue, and the CDC's COVID-19 Data Tracker will still track vaccination data. COVID-19 deaths will be reported based on death certificates for more accuracy, and genomic sequencing of positive samples will continue to monitor for new variants.

The pandemic has left a lasting impact on millions of lives. An estimated 245,000 children in the US have lost one or both parents to COVID-19, with around 10.5 million COVID orphans worldwide. Despite the profound implications, COVID orphans have been largely overlooked in policy responses to the pandemic. In February, California began working on a $100 million fund for COVID orphans and children in foster care when they turn 18, but this has not been replicated elsewhere in the US. The federal government has yet to address the issue directly with national policies or programs. Children of color have been disproportionately affected, with Black children in the US twice as likely as white children to have suffered the loss of a parent or caregiver. Half of the US children who have lost one or both parents live in California, Texas, Florida, New York, and Georgia.

As we move forward, it's crucial to remember the lives lost and the families affected by this devastating virus. While the global emergency may be over, the fight against COVID-19 is far from finished. We must continue to be vigilant, maintain pandemic preparedness and response plans, and ensure that those who have been affected by the virus receive the support they need. The end of the global emergency is a significant step towards a new normal, but there is still much work to be done in the battle against COVID-19.

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The small Ukrainian town of Bakhmut has become a battleground for both Russian and Ukrainian forces, with the months-long assault led by Russia's paramilitary Wagner Group resulting in significant casualties. Despite its limited strategic value, the battle for Bakhmut holds symbolic importance for both sides.

Tensions have emerged between the Wagner Group, led by Yevgeny Prigozhin, and the conventional Russian army, as Prigozhin threatened to withdraw his forces from Bakhmut due to insufficient ammunition supplies. In response, the Russian army has promised more ammunition to the mercenaries. Ukrainian officials aim to deplete Russian reserves by inflicting as many casualties as possible. Although Russia seeks control over the entire Donetsk region, Ukrainian forces have maintained control over a small portion of Bakhmut and pushed back Russian troops in some areas.

Ukraine has accused Russia of a phosphorus attack on Bakhmut, which would constitute a war crime. Drone footage shows the city ablaze, but the use of white phosphorus could not be verified. The Wagner Group's involvement also raises concerns about war crimes, as videos allegedly showing beheaded Ukrainian soldiers have emerged on social media. Ukrainian President Volodymyr Zelensky has vowed to hold the perpetrators accountable, while Kremlin spokesperson Dmitry Peskov calls for verifying the authenticity of the footage.

Two men claiming to be former Wagner Group members have confessed to killing dozens of children in Ukraine and their comrades who refused to fight. Ukrainian prosecutors have initiated investigations into these testimonies, while Yevgeny Prigozhin denies the allegations and threatens punishment against the men.

The battle for Bakhmut underscores the complexities and brutalities of the war in Ukraine, with mounting human costs and questions about war crimes and the involvement of private military groups like the Wagner Group. As the deadline for Prigozhin's ultimatum to the Russian Defense Minister over ammunition shortages has passed, the outcome remains uncertain and its impact on the larger conflict remains to be seen.

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