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News That Matters

20/01/2023 ---- 13/02/2023

PFAS (Per- and poly-fluoroalkyl substances) are a group of artificial chemicals used in various consumer and industrial products, including nonstick cookware, water-resistant clothing, stain-resistant textiles and upholstery, food packaging, and fire-fighting foams. They are very stable, non-biodegradable and resistant to heat, water, and oil, making them ideal for various applications. They can be found in food packaging, cosmetics, cookware, waterproof clothing, carpets, mattresses, electronics and fire-fighting foams. In industry, they are used in processes such as metal finishing and plating, hydraulic fluids and semiconductor manufacturing. However, they are also known to persist in the environment. For this reason, they are a family of thousands of substances nicknamed “forever chemicals”.

There is growing concern about the potential health effects of PFAS exposure, as they can accumulate in the bodies of humans and wildlife over time. Some studies have linked these chemicals to various health problems, including kidney and testicular cancer, developmental issues, thyroid disease, and low birth weight. As a result, many countries are taking steps to regulate or restrict the use of PFAS. The use of two of these substances – PFOS and PFOA – have been banned or limited because of their toxic, persistent and bioaccumulative effects. Still, there are concerns about others with less toxicity evidence available because they have been less studied.

A recent study by scientists at Oxford University found that Norwegian Artic ice is contaminated with alarming levels of toxic PFAS. The scientists detected 26 types of PFAS compounds. They found that the chemicals can move from glaciers into downstream ecosystems like Arctic fjords and tundra when the ice melts. The meltwater can contain a cocktail of contaminants that includes PFAS and affects the entire food web, including plankton, fish, seal and apex animals like polar bears, which have previously been found to have high PFAS levels in their blood. The chemicals may represent a significant environmental stressor to the region’s wildlife. The study also found exceptionally high levels of TFA, a refrigeration byproduct. During the Montreal Protocol in 1987, many nations agreed to phase out chlorofluorocarbons, or CFCs, a potent greenhouse gas used for refrigeration. Those were ultimately replaced with hydrofluoric-olefin or HFOs. Once in the environment, HFOs, which are also greenhouse gases, can turn into TFA, and TFA levels are increasing in the Arctic. TFA and other PFAS compounds are highly mobile. They can move through the atmosphere to be deposited in the Arctic or elsewhere.

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Artificial Intelligence, commonly referred to as AI, refers to the development of computer systems that can perform tasks typically requiring human intelligence, such as visual perception, speech recognition, decision-making, and language translation. It has been a field of study and research for several decades. In recent years, it has experienced a surge in popularity and advancements. It is widely believed that AI is the next revolution for humanity, with the potential to revolutionize virtually every industry and aspect of our lives. AI is already being applied in numerous fields, including healthcare, finance, retail, transportation, and manufacturing. In healthcare, AI improves patient outcomes by analyzing large amounts of medical data, enabling doctors to make more accurate diagnoses. In finance, AI is used to identify fraud and make investment decisions. In retail, AI personalizes customer experiences and optimizes supply chains. In transportation, AI improves traffic flow and makes autonomous vehicles a reality.

2023 will be a pivotal year for the development of AI as more and more companies adopt this technology to improve their operations and gain a competitive edge. OpenAI, a leading AI research institute in this field, has made significant advancements. OpenAI has released ChatGPT, a large language model, as an essential step towards advancing the field of AI and making it more accessible to the public. Since the release of this public model through the OpenAI website, Microsoft has decided to invest 1.5 billion dollars. It seeks to integrate it into the upcoming software products. Google, on the other hand, in early February invested 300 million dollars in artificial intelligence start-up Anthropic, making it the latest tech giant to throw its money and computing power behind a new generation of companies trying to claim a place in the booming field of “generative AI”. Anthropic was formed in 2021 when a group of researchers led by Dario Amodei left OpenAI after a disagreement over the company’s direction.

Today AI is a rapidly growing field that has the potential to transform the way we live and work. The advancements made in AI in recent years have been nothing short of remarkable, and 2023 promises to be a year of even more remarkable progress. It is today clear that the future of AI is bright, and we are only scratching the surface of its potential.

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Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections more complicated to treat and increasing the risk of disease spread, severe illness and death. Antimicrobials, including antibiotics, antivirals, antifungals and antiparasitics, are medicines used to treat infections in humans, animals and plants. As a result of drug resistance, antibiotics and other antimicrobial medications become ineffective, and infections become increasingly difficult or impossible to treat. The emergence and spread of drug-resistant pathogens that have acquired new resistance mechanisms, leading to antimicrobial resistance, continue to threaten our ability to treat common infections. In general, it is through the intensive use of antibiotics that microbes evolve to become resistant. Especially alarming is the rapid global spread of multi- and pan-resistant bacteria (also known as "superbugs") that cause infections that are not treatable with existing antimicrobial medicines such as antibiotics. On top of this growing issue, the clinical pipeline of new antimicrobials is "dry". In 2019, the World Health Organization (WHO) identified 32 antibiotics in clinical development that address the WHO list of priority pathogens, of which only six were classified as innovative.

A significant contribution to antimicrobial resistance is the use of antibiotics in animal farming. Although antibiotics can be necessary to treat infections in livestock, they are often used to speed up animal growth and prevent diseases among animals in crowded, unsanitary conditions. Researchers struggle to calculate the antibiotics used in particular countries because most do not publicly release their agricultural-antibiotic usage data. Many release the data to the World Organization for Animal Health (WOAH), which groups countries' antibiotics data into continents - so that is all that researchers can see. However, around 40% of countries do not report antibiotic use. Two epidemiologists at the Swiss federal institute of technology (ETH) analysed antibiotic usage in animal farming by collecting data from individual governments, farm surveys and scientific articles that reported veterinary use of antibiotics. They cross-referenced these with data on farm-animal populations worldwide and on antibiotic sales from the 42 countries that reported those data publicly. The team calculated that antibiotic use in Africa is probably twice what WOAH writes, and use in Asia is 50% higher than reported. China is currently using more antibiotics in farming than any other country. Pakistan will experience the highest use growth between 2020 and 2030. The researchers also estimate that antibiotic use will grow the fastest in Africa, rising by 25% between 2020 and 2030 owing to increased demand for meat products. Making usage data more publicly accessible could lead to increased accountability for countries and agricultural producers that do not use antibiotics responsibly.

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A powerful earthquake hit Southern Turkey and Northern Syria in the early hours of Monday morning. According to the Turkish and Syrian authorities, thousands of people have been injured, and hundreds have been found dead. The 7.8 magnitude heartquake struck near the city of Gaziantep, near the border with Syria. Turkish President Recep Tayyip Erdogan has said on Twitter that "search and rescue teams were immediately dispatched" to the areas hit by the quake. Residents have been helping rescue workers to pull survivors among the debris. To complicate the intervention, ice and snow are covering roads. The earthquake's impact was so huge that tremors could be felt in Lebanon, Cyprus, and Egypt. In Damascus, buildings shook, and many people rushed onto the streets in fear. In a briefing, Turkey's vice president said that around 1,700 buildings had collapsed. Syria's state media also reported that some buildings had collapsed in Aleppo and the central city of Hama. Authorities confirmed that this is, so far, the most powerful earthquake on record in the region. However, heartquakes are not new in the zone: in 2011 and 1999, two more were hit with a power magnitude of 7.1 and 7.6, respectively. The reaction from international leaders was prompt in offering assistance to Turkey and Syria. Germany, the US, the EU and all NATO members expressed complete solidarity and are now coordinating interventions with President Erdogan.

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Coral reefs are one of the most threatened marine systems. Scientists estimate that unless we take immediate action, we could lose up to 90% of coral reefs within our lifetimes. Florida's Coral Reef is the largest coral reef ecosystem in the continental U.S., with its extensive shallow coral reefs that span 358 miles from the Dry Tortugas near Key West, north along the Atlantic coast to Martin County. Colourful parrotfish, angelfish, wrasses, barracuda, nurse sharks, stingrays, delicate corals, other invertebrates and turtles are all inhabitants of Florida's beautiful coral reefs. The coral reefs provide Florida with many benefits. Not only are they home to many species of wildlife, including those listed as Threatened under the Endangered Species Act. They are also integral to Florida's economy, supporting our tourism industry and commercial and recreational fisheries. Additionally, they act as a natural buffer for Florida's shoreline, helping to lessen the strength of waves and providing natural support for coastal resilience.

Coral reef communities are sensitive to threats linked to people's actions. From high water temperatures, which are dangerous to corals, to pollutants that impact the ecosystem's health, to our commercial and recreational uses of the reef, sound science-based management practices and careful stewardship are critical to ensure the reefs' health future. A recent outbreak of stony coral tissue loss disease threatens to destroy 20 of 45 species found here. It is still unknown what is causing this. To save the reef, a team of scientists from The Nature Conservancy has moved some species to a lab in Orlando where they simulate breeding conditions, LED and lights replicate the sun and moon cycles, and volunteers feed the coral in water treated to mimic its natural habitat. That is the first time many volunteers are involved in rescuing an entire ecosystem. They now seek to collaborate with the Florida Department of Environmental Protection to develop and implement a more detailed restoration plan. Hopefully, the aim of saving Florida's reef will be achieved.

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The territorial dispute between Jews and Palestinians revolves around the control and ownership of land, particularly in the West Bank and East Jerusalem. Jews have claimed the land as their ancestral homeland and see it as their right to live there. Palestinians, on the other hand, see the West Bank and East Jerusalem as part of a future Palestinian state and argue that the presence of Israeli settlements is illegal under international law. The conflict over the territory has been ongoing for decades, with both sides claiming rights to the land and engaging in acts of violence and conflict to support their claims. Efforts to resolve the dispute and find a peaceful solution have been made through negotiations and peace processes. Still, a final resolution has yet to be reached. Last week, within a few days, there were reciprocal attacks and acts of violence between Palestinians and Israelis. It all started Thursday, January 26, with an Israeli army military operation in the West Bank, in the Jenin refugee camp, in which 10 Palestinians were killed, which was followed first by an exchange of missiles and rockets between Israel and the Gaza Strip, and then between Friday and Saturday two attacks by Palestinians in East Jerusalem. In the first, the most serious, a 21-year-old man killed seven people while leaving a synagogue: not so many people have been killed in a single attack in Jerusalem for 15 years.

The origin of this conflict has old roots. Jerusalem's Old City is divided into four quarters: Muslim, Christian, Jewish, and Armenian. The Eastern part of the Old City is called the "East Jerusalem" and holds significant religious and cultural importance for Jews, Muslims, and Christians. In the 7th century, Jerusalem was conquered by Arab forces and became a cultural centre for Islam. The city remained under Muslim control until the First Crusade in 1099 when Christian knights captured the city and established the Kingdom of Jerusalem. In 1187, the city was retaken by Muslim warrior Saladin, who became a hero in Islamic history. During Ottoman rule, Jerusalem's East became a predominantly Muslim neighbourhood. In 1917, British forces captured the city during World War I and established the British Mandate in Palestine. The conflict between Jews and Arabs over control of Palestine and the city of Jerusalem escalated in the 20th century, leading to the 1948 Arab-Israeli War and the establishment of Israel. In the 1967 Six-Day War, Israel captured and reunified the Old City of Jerusalem. Today, the Old City is a major tourist destination and pilgrimage site for people of different faiths, with the Temple Mount and the Western Wall, both revered by Jews, the Church of the Holy Sepulchre, one of Christianity's holiest sites, and the Al-Aqsa Mosque, a primary Islamic site, located in Jerusalem's East.

Since December 2022, a new government by Benjamin Netanyahu has been formed, and tensions between Israelis and Palestinians have grown significantly. The government is the most right-end in Israel's history. It includes ministers, such as Itamar Ben-Gvir, holding a strong nationalist ideology. Itamar Ben-Gvir is known for his controversial views on issues such as Israeli settlements in the West Bank, Palestinian statehood, and the treatment of Arab Israelis. He is a vocal opponent of the peace process. He has been associated with several acts of extremism and incitement, leading many to view him as a divisive figure in Israeli politics. The international community is notoriously divided over the issue of Israeli control of East Jerusalem. Some countries recognize Israel's sovereignty over the city, while others do not. The issue has led to debates and negotiations, with some countries supporting Israel and others supporting the Palestinians. Despite international efforts to resolve the conflict, the situation remains unresolved, and tensions continue to simmer in Jerusalem and the wider region.

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Pathogenic fungi are common fungi that cause disease in humans or other organisms. Approximately 300 fungi are pathogenic to humans, mainly to immune-compromised subjects such as HIV-infected or organ-transplanted people. Among pathogenic fungi, we find Candida, Aspergillus, and Cryptococcus, which can cause diseases such as vaginal candidiasis, fungal nail infection, aspergillosis and cryptococcus infection. Healthy people with a functional immune system usually don't have to worry about these diseases since symptoms disappear without treatment.

However, all that may be about to change: a new study by a team of scientists at Duke University School of Medicine and published on January 20 in the Proceedings of the National Academy of Sciences finds that raised temperatures can cause a pathogenic fungus - known as Cryptococcus deneoformans - to turn its adaptative responses. Briefly, high temperatures increase its genetic changes, some of which may lead to higher heat resistance and more significant disease-causing potential. Specifically, higher heat induces changes in a specific region of its DNA called jumping genes, thus allowing the fungus to adapt to extreme environmental conditions (and, therefore, to increased resilience in general). The study suggests that high temperatures may contribute to the evolution of pathogenic traits in fungi during infection. Similar mechanisms in various fungi species may evolve faster than expected due to rising global temperatures.

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Body hair is a defining mammalian characteristic, but several mammals, such as whales, naked mole rats and humans, have notably less hair. The evolutionary mechanism of body hair loss is well understood: some animals do not have hair on their entire body because it is not necessary for survival or reproduction. For example, certain marine mammals, such as dolphins and whales, have little to no body hair because it would harm their ability to swim efficiently. Similarly, some animals that live in hot environments may have less hair as it helps them to regulate their body temperature. It is believed that also humans have evolved to have hairless skin because it allows them to regulate their body temperature. Humans have evolved to have efficient sweat glands, which help them to cool down by sweating. Fur can trap heat and make it difficult for an organism to cool down, which would be detrimental in hot environments. Additionally, the development of clothing and other body coverings has also made fur unnecessary for human survival.

Even though all these facts are known and understood, the genetic mechanism of body hair growth is still a mystery. A recent study by scientists from the University of Utah, published in the journal Elife, unlocked the mystery by examining how hairlessness evolved in different species at different times. By comparing the human genetic code with those of 62 other mammals, including elephants, manatees and chimpanzees, they managed to identify the genes involved in the expression of body hair. To find the genetic basis of reduced hair quantity, the scientists compared more than 19,000 genes and, through cutting-edge methods, narrowed their focus to those linked to keeping or losing body hair. Many genes linked to hair growth contain instructions for making the protein keratin, which forms hair, nails and the skin’s outer layer. The authors found that although the genes for a complete covering of body hair remain in our genetic code, they have been muted and lost their function.

This study marks the first time genetic mechanisms behind various hair traits have been studied in such a diverse group of mammals. Using a novel computational approach, which allows for estimating the genome evolution rate, the research team was able to identify genes and processes that no one knew to be involved in hair growth or hairlessness in mammals. This study and the method used may pave the way for finding out how to treat genetic conditions such as baldness.

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Over the past 50 years, the world has witnessed a steep decline in fertility rates in virtually every country on Earth. The global fertility rate measures how many children per couple are born yearly. Worldwide, it changed from a value of 5 in 1951 to a value of 2.4 in 2022 - a decrease of more than 50%. While this measures the world average, it is worth noting that the fertility rate changes radically among different countries. While many African countries maintain high fertility rates, the countries driving the world's economy had 2022 fertility rates below the so-called "replacement threshold", which is the rate required to maintain the population - identified in a value of 2. For instance, the EU has a fertility rate of 1.6, with low peaks in Italy and Greece at about 1.3. China had 1.7, the US 1.8, all the way down to 1.4 and 1.1 for Japan and South Korea, respectively.

The main reasons for the decline are the social factors related to increasing prosperity. The most relevant aspect is access to high education, which delays the decision to conceive a baby for many couples. The social condition of women has improved drastically in the latest decades, which caused many to delay procreation to favour career development. Age is undoubtedly the most critical factor affecting a woman's fertility. While good health improves the chance of getting pregnant and having a healthy baby, it doesn't override the effects of age. A woman in her early to mid-20s has a 25–30% chance of getting pregnant every month. Fertility generally starts to reduce when a woman is in her early 30s and more so after age 35. By age 40, the chance of getting pregnant in any monthly cycle is only around 5%.

On top of this trend, it recently became clear that environmental and lifestyle factors also have an essential impact. Besides increasing obesity in the population, which is known to hinder procreation, a recent study published in Human Reproduction Update reported for the first time an analysis of the evolution of sperm quality. The result of the study indicates that, over the past 50 years, human sperm counts have fallen by more than 50% around the globe. If the findings are confirmed and the decline continues, it could have important implications for human reproduction. The review, and its conclusions, have sparked a debate among experts. Some say the findings are real and urgent, but others say the data do not convince them. However, more studies are being published to find possible explanations for this trend. For example, scientists observed the harmful effects of microplastics - already known to harm several lifeforms - on male reproduction and sperm quality. More scrutiny is also dedicated to the several chemicals employed throughout modern societies.

Arguably, many elements are driving our species into an infertility trap. If we are to avoid it, it is vital to adopt social, political, environmental and lifestyle changes to bring this situation under control. For the first time, a robust political signal was launched in this direction just a few days ago by Japan Prime Minister Fumio Kishida, who openly recognized the country's population crisis and its implications for Japan's economy. He said Japan was "on the brink of being unable to maintain social functions" due to the falling birth rate. In a policy address to lawmakers, Fumio Kishida said it was a case of solving the issue "now or never" and that it "simply cannot wait any longer. In thinking of the sustainability and inclusiveness of our nation's economy and society, we place child-rearing support as our most important policy". Kishida added that he wants the government to double its spending on child-related programs and that a new government agency would be set up in April to focus on the issue.

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The tensions between the European Union and Russia have grown over the Ukraine war in the last two months. They reached a maximum during the night between November 15 and 16, 2022, when two explosions by Russian-made missiles reached a small village in Poland, right at the border with Ukraine, making two dead. An emergency meeting was held between NATO and G7 members (the G20 in Bali was ongoing then). However, a confrontation did not occur, with Russia denying responsibility and the uncertainty of the strike source. After the event, Russia hit the whole Ukraine territory with missiles, mainly targeting energy and military facilities, civil buildings, and city centres.

Consequently, on November 23, the European Parliament declared Russia a "state sponsor of terrorism" over the "brutal and inhumane" acts inflicted upon Ukraine and its citizens since the launch of the invasion. A few hours after the vote, the EU Parliament's official website was down due to a "sophisticated cyberattack". The European Parliament President Roberta Metsola declared that a pro-Kremlin group had claimed responsibility. In the meantime, Kyiv was left without water and electricity after new Russian strikes caused power outages across Ukraine and neighbouring Moldova. Authorities in Lviv, western Ukraine, also reported that the "whole city" was without electricity after fresh Russian rocket attacks. The Russian strikes continued in the following weeks. Due to the Russian strikes, on November 25, more than 6 million households were without power, said Ukrainian President Volodymyr Zelensky.

On December 2, Russian President Vladimir Putin met his German counterpart, Olaf Scholz, over the phone. He told him that Moscow's attacks on Ukraine's infrastructure were "inevitable". The Kremlin raised attention to the destructive line of Western states, including Germany, pumping the Kyiv regime with weapons and training the Ukrainian military. Putin said that "political and financial support" from Ukraine's Western allies leads to the fact that Kyiv completely rejects the idea of any negotiations. On the other hand, Scholz condemned Russian airstrikes against civilian infrastructure in Ukraine and stressed Germany's determination to support the Ukrainians in ensuring their defence capabilities against Russian aggression. In the meantime, the European Union reached a consensus on the price to cap Russian oil just days before its ban on most imports comes into force. The bloc's 27 member states agreed to set the cap at $60 a barrel. Although Russia previously warned that it would stop supplying countries that adhere to the cap, it means that their income from oil sales will necessarily decrease.

On December 5, attacks killed three people and damaged two strategic nuclear bombers in separate blasts at two Russian airfields. One of these airfields - Engels, located 500 kilometres east of Ukraine's border in the Saratov region - was attacked through drones. The other, located southeast of Moscow, was hit by a fuel tanker explosion that caused the three deaths. Russian regional governors have repeatedly blamed Ukraine for these cross-border attacks on their soil. Still, Kyiv has neither confirmed nor denied responsibility. Russian massive attacks continued until the end of December, leaving millions without electricity in the upcoming winter.

In December, several bilateral meetings took place where leaders discussed the Ukraine crisis. On December 1, Chinese President Xi Jinping and visiting President of the European Council Charles Michel met to strengthen strategic communication and cooperation between the EU and China. Among other topics, Xi and Michel exchanged views on the Ukraine crisis. Xi expounded on China's position, noting that a political settlement of the crisis best serves Europe's interests and the common interests of all countries in Eurasia. China will remain on the side of peace and continue to play a constructive role in its way, Xi said. On December 19, Putin visited his close ally and strongman Alexander Lukashenko in Belarus. His arrival in Minsk came hours after Russian forces launched a swarm of attack drones at critical infrastructure in Kyiv, which provoked emergency blackouts in a dozen Ukrainian regions. Belarus, which relies on Moscow for cheap oil and loans, has so far resisted outright unification with Russia despite being a key ally in the war. However, earlier in October, Belarus announced the formation of a joint regional force with Moscow, fuelling concerns Minsk could also send troops to Ukraine. Until today, however, Belarus did not directly join the war. On December 22, Ukrainian President Volodymyr Zelensky visited Washington to thank US leaders and the Americans for their support. He pledged there would be "no compromises" in trying to bring an end to the war. President Joe Biden and Congress responded with billions in new assistance and a pledge to help Ukraine pursue a "just peace." Mr Zelensky said that "just peace is no compromises. The war would end once we restore Ukraine's sovereignty, freedom and territorial integrity."

On January 5, Putin met Turkish President Recep Tayyip Erdogan in a phone conversation. In light of Erdogan's readiness to mediate a political solution to the conflict, Putin reiterated that Russia is open to serious dialogue. He added that Kyiv must meet demands, with the due account taken of the new territorial realities. According to the Kremlin, Putin and Erdogan also discussed the agreements reached in Istanbul to export Ukrainian grain and unblock Russian food and fertilizer exports. A few hours after the call, Putin ordered his troops to observe a temporary ceasefire in Ukraine over Orthodox Christmas on Jan. 6-7. However, this pause did not lead to any negotiation table, with Kyiv accusing the Kremlin of "cynical propaganda".

The Ukraine crisis has yet to have a favourable negotiation in sight today. In the last few weeks, the US and its allies have decided further to sustain the Ukrainian army in its military objectives. On January 19, the US expressed its will to support Ukraine in retaking all territory until Crimea. These days the allies are deciding on providing long-range missiles, tanks, and new weapons to Ukraine. A lengthy debate revolved around providing German-made Leopard tanks to Ukraine, which was approved today, January 23. In the meantime, the Kremlin is threatening that new weapons for Kyiv will cause a 'global catastrophe' as it is pushing the world to a terrible war.

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