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News That Matters

26/01/2023 ---- 08/02/2023

Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections more complicated to treat and increasing the risk of disease spread, severe illness and death. Antimicrobials, including antibiotics, antivirals, antifungals and antiparasitics, are medicines used to treat infections in humans, animals and plants. As a result of drug resistance, antibiotics and other antimicrobial medications become ineffective, and infections become increasingly difficult or impossible to treat. The emergence and spread of drug-resistant pathogens that have acquired new resistance mechanisms, leading to antimicrobial resistance, continue to threaten our ability to treat common infections. In general, it is through the intensive use of antibiotics that microbes evolve to become resistant. Especially alarming is the rapid global spread of multi- and pan-resistant bacteria (also known as "superbugs") that cause infections that are not treatable with existing antimicrobial medicines such as antibiotics. On top of this growing issue, the clinical pipeline of new antimicrobials is "dry". In 2019, the World Health Organization (WHO) identified 32 antibiotics in clinical development that address the WHO list of priority pathogens, of which only six were classified as innovative.

A significant contribution to antimicrobial resistance is the use of antibiotics in animal farming. Although antibiotics can be necessary to treat infections in livestock, they are often used to speed up animal growth and prevent diseases among animals in crowded, unsanitary conditions. Researchers struggle to calculate the antibiotics used in particular countries because most do not publicly release their agricultural-antibiotic usage data. Many release the data to the World Organization for Animal Health (WOAH), which groups countries' antibiotics data into continents - so that is all that researchers can see. However, around 40% of countries do not report antibiotic use. Two epidemiologists at the Swiss federal institute of technology (ETH) analysed antibiotic usage in animal farming by collecting data from individual governments, farm surveys and scientific articles that reported veterinary use of antibiotics. They cross-referenced these with data on farm-animal populations worldwide and on antibiotic sales from the 42 countries that reported those data publicly. The team calculated that antibiotic use in Africa is probably twice what WOAH writes, and use in Asia is 50% higher than reported. China is currently using more antibiotics in farming than any other country. Pakistan will experience the highest use growth between 2020 and 2030. The researchers also estimate that antibiotic use will grow the fastest in Africa, rising by 25% between 2020 and 2030 owing to increased demand for meat products. Making usage data more publicly accessible could lead to increased accountability for countries and agricultural producers that do not use antibiotics responsibly.

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A powerful earthquake hit Southern Turkey and Northern Syria in the early hours of Monday morning. According to the Turkish and Syrian authorities, thousands of people have been injured, and hundreds have been found dead. The 7.8 magnitude heartquake struck near the city of Gaziantep, near the border with Syria. Turkish President Recep Tayyip Erdogan has said on Twitter that "search and rescue teams were immediately dispatched" to the areas hit by the quake. Residents have been helping rescue workers to pull survivors among the debris. To complicate the intervention, ice and snow are covering roads. The earthquake's impact was so huge that tremors could be felt in Lebanon, Cyprus, and Egypt. In Damascus, buildings shook, and many people rushed onto the streets in fear. In a briefing, Turkey's vice president said that around 1,700 buildings had collapsed. Syria's state media also reported that some buildings had collapsed in Aleppo and the central city of Hama. Authorities confirmed that this is, so far, the most powerful earthquake on record in the region. However, heartquakes are not new in the zone: in 2011 and 1999, two more were hit with a power magnitude of 7.1 and 7.6, respectively. The reaction from international leaders was prompt in offering assistance to Turkey and Syria. Germany, the US, the EU and all NATO members expressed complete solidarity and are now coordinating interventions with President Erdogan.

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Coral reefs are one of the most threatened marine systems. Scientists estimate that unless we take immediate action, we could lose up to 90% of coral reefs within our lifetimes. Florida's Coral Reef is the largest coral reef ecosystem in the continental U.S., with its extensive shallow coral reefs that span 358 miles from the Dry Tortugas near Key West, north along the Atlantic coast to Martin County. Colourful parrotfish, angelfish, wrasses, barracuda, nurse sharks, stingrays, delicate corals, other invertebrates and turtles are all inhabitants of Florida's beautiful coral reefs. The coral reefs provide Florida with many benefits. Not only are they home to many species of wildlife, including those listed as Threatened under the Endangered Species Act. They are also integral to Florida's economy, supporting our tourism industry and commercial and recreational fisheries. Additionally, they act as a natural buffer for Florida's shoreline, helping to lessen the strength of waves and providing natural support for coastal resilience.

Coral reef communities are sensitive to threats linked to people's actions. From high water temperatures, which are dangerous to corals, to pollutants that impact the ecosystem's health, to our commercial and recreational uses of the reef, sound science-based management practices and careful stewardship are critical to ensure the reefs' health future. A recent outbreak of stony coral tissue loss disease threatens to destroy 20 of 45 species found here. It is still unknown what is causing this. To save the reef, a team of scientists from The Nature Conservancy has moved some species to a lab in Orlando where they simulate breeding conditions, LED and lights replicate the sun and moon cycles, and volunteers feed the coral in water treated to mimic its natural habitat. That is the first time many volunteers are involved in rescuing an entire ecosystem. They now seek to collaborate with the Florida Department of Environmental Protection to develop and implement a more detailed restoration plan. Hopefully, the aim of saving Florida's reef will be achieved.

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The territorial dispute between Jews and Palestinians revolves around the control and ownership of land, particularly in the West Bank and East Jerusalem. Jews have claimed the land as their ancestral homeland and see it as their right to live there. Palestinians, on the other hand, see the West Bank and East Jerusalem as part of a future Palestinian state and argue that the presence of Israeli settlements is illegal under international law. The conflict over the territory has been ongoing for decades, with both sides claiming rights to the land and engaging in acts of violence and conflict to support their claims. Efforts to resolve the dispute and find a peaceful solution have been made through negotiations and peace processes. Still, a final resolution has yet to be reached. Last week, within a few days, there were reciprocal attacks and acts of violence between Palestinians and Israelis. It all started Thursday, January 26, with an Israeli army military operation in the West Bank, in the Jenin refugee camp, in which 10 Palestinians were killed, which was followed first by an exchange of missiles and rockets between Israel and the Gaza Strip, and then between Friday and Saturday two attacks by Palestinians in East Jerusalem. In the first, the most serious, a 21-year-old man killed seven people while leaving a synagogue: not so many people have been killed in a single attack in Jerusalem for 15 years.

The origin of this conflict has old roots. Jerusalem's Old City is divided into four quarters: Muslim, Christian, Jewish, and Armenian. The Eastern part of the Old City is called the "East Jerusalem" and holds significant religious and cultural importance for Jews, Muslims, and Christians. In the 7th century, Jerusalem was conquered by Arab forces and became a cultural centre for Islam. The city remained under Muslim control until the First Crusade in 1099 when Christian knights captured the city and established the Kingdom of Jerusalem. In 1187, the city was retaken by Muslim warrior Saladin, who became a hero in Islamic history. During Ottoman rule, Jerusalem's East became a predominantly Muslim neighbourhood. In 1917, British forces captured the city during World War I and established the British Mandate in Palestine. The conflict between Jews and Arabs over control of Palestine and the city of Jerusalem escalated in the 20th century, leading to the 1948 Arab-Israeli War and the establishment of Israel. In the 1967 Six-Day War, Israel captured and reunified the Old City of Jerusalem. Today, the Old City is a major tourist destination and pilgrimage site for people of different faiths, with the Temple Mount and the Western Wall, both revered by Jews, the Church of the Holy Sepulchre, one of Christianity's holiest sites, and the Al-Aqsa Mosque, a primary Islamic site, located in Jerusalem's East.

Since December 2022, a new government by Benjamin Netanyahu has been formed, and tensions between Israelis and Palestinians have grown significantly. The government is the most right-end in Israel's history. It includes ministers, such as Itamar Ben-Gvir, holding a strong nationalist ideology. Itamar Ben-Gvir is known for his controversial views on issues such as Israeli settlements in the West Bank, Palestinian statehood, and the treatment of Arab Israelis. He is a vocal opponent of the peace process. He has been associated with several acts of extremism and incitement, leading many to view him as a divisive figure in Israeli politics. The international community is notoriously divided over the issue of Israeli control of East Jerusalem. Some countries recognize Israel's sovereignty over the city, while others do not. The issue has led to debates and negotiations, with some countries supporting Israel and others supporting the Palestinians. Despite international efforts to resolve the conflict, the situation remains unresolved, and tensions continue to simmer in Jerusalem and the wider region.

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Pathogenic fungi are common fungi that cause disease in humans or other organisms. Approximately 300 fungi are pathogenic to humans, mainly to immune-compromised subjects such as HIV-infected or organ-transplanted people. Among pathogenic fungi, we find Candida, Aspergillus, and Cryptococcus, which can cause diseases such as vaginal candidiasis, fungal nail infection, aspergillosis and cryptococcus infection. Healthy people with a functional immune system usually don't have to worry about these diseases since symptoms disappear without treatment.

However, all that may be about to change: a new study by a team of scientists at Duke University School of Medicine and published on January 20 in the Proceedings of the National Academy of Sciences finds that raised temperatures can cause a pathogenic fungus - known as Cryptococcus deneoformans - to turn its adaptative responses. Briefly, high temperatures increase its genetic changes, some of which may lead to higher heat resistance and more significant disease-causing potential. Specifically, higher heat induces changes in a specific region of its DNA called jumping genes, thus allowing the fungus to adapt to extreme environmental conditions (and, therefore, to increased resilience in general). The study suggests that high temperatures may contribute to the evolution of pathogenic traits in fungi during infection. Similar mechanisms in various fungi species may evolve faster than expected due to rising global temperatures.

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Body hair is a defining mammalian characteristic, but several mammals, such as whales, naked mole rats and humans, have notably less hair. The evolutionary mechanism of body hair loss is well understood: some animals do not have hair on their entire body because it is not necessary for survival or reproduction. For example, certain marine mammals, such as dolphins and whales, have little to no body hair because it would harm their ability to swim efficiently. Similarly, some animals that live in hot environments may have less hair as it helps them to regulate their body temperature. It is believed that also humans have evolved to have hairless skin because it allows them to regulate their body temperature. Humans have evolved to have efficient sweat glands, which help them to cool down by sweating. Fur can trap heat and make it difficult for an organism to cool down, which would be detrimental in hot environments. Additionally, the development of clothing and other body coverings has also made fur unnecessary for human survival.

Even though all these facts are known and understood, the genetic mechanism of body hair growth is still a mystery. A recent study by scientists from the University of Utah, published in the journal Elife, unlocked the mystery by examining how hairlessness evolved in different species at different times. By comparing the human genetic code with those of 62 other mammals, including elephants, manatees and chimpanzees, they managed to identify the genes involved in the expression of body hair. To find the genetic basis of reduced hair quantity, the scientists compared more than 19,000 genes and, through cutting-edge methods, narrowed their focus to those linked to keeping or losing body hair. Many genes linked to hair growth contain instructions for making the protein keratin, which forms hair, nails and the skin’s outer layer. The authors found that although the genes for a complete covering of body hair remain in our genetic code, they have been muted and lost their function.

This study marks the first time genetic mechanisms behind various hair traits have been studied in such a diverse group of mammals. Using a novel computational approach, which allows for estimating the genome evolution rate, the research team was able to identify genes and processes that no one knew to be involved in hair growth or hairlessness in mammals. This study and the method used may pave the way for finding out how to treat genetic conditions such as baldness.

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Over the past 50 years, the world has witnessed a steep decline in fertility rates in virtually every country on Earth. The global fertility rate measures how many children per couple are born yearly. Worldwide, it changed from a value of 5 in 1951 to a value of 2.4 in 2022 - a decrease of more than 50%. While this measures the world average, it is worth noting that the fertility rate changes radically among different countries. While many African countries maintain high fertility rates, the countries driving the world's economy had 2022 fertility rates below the so-called "replacement threshold", which is the rate required to maintain the population - identified in a value of 2. For instance, the EU has a fertility rate of 1.6, with low peaks in Italy and Greece at about 1.3. China had 1.7, the US 1.8, all the way down to 1.4 and 1.1 for Japan and South Korea, respectively.

The main reasons for the decline are the social factors related to increasing prosperity. The most relevant aspect is access to high education, which delays the decision to conceive a baby for many couples. The social condition of women has improved drastically in the latest decades, which caused many to delay procreation to favour career development. Age is undoubtedly the most critical factor affecting a woman's fertility. While good health improves the chance of getting pregnant and having a healthy baby, it doesn't override the effects of age. A woman in her early to mid-20s has a 25–30% chance of getting pregnant every month. Fertility generally starts to reduce when a woman is in her early 30s and more so after age 35. By age 40, the chance of getting pregnant in any monthly cycle is only around 5%.

On top of this trend, it recently became clear that environmental and lifestyle factors also have an essential impact. Besides increasing obesity in the population, which is known to hinder procreation, a recent study published in Human Reproduction Update reported for the first time an analysis of the evolution of sperm quality. The result of the study indicates that, over the past 50 years, human sperm counts have fallen by more than 50% around the globe. If the findings are confirmed and the decline continues, it could have important implications for human reproduction. The review, and its conclusions, have sparked a debate among experts. Some say the findings are real and urgent, but others say the data do not convince them. However, more studies are being published to find possible explanations for this trend. For example, scientists observed the harmful effects of microplastics - already known to harm several lifeforms - on male reproduction and sperm quality. More scrutiny is also dedicated to the several chemicals employed throughout modern societies.

Arguably, many elements are driving our species into an infertility trap. If we are to avoid it, it is vital to adopt social, political, environmental and lifestyle changes to bring this situation under control. For the first time, a robust political signal was launched in this direction just a few days ago by Japan Prime Minister Fumio Kishida, who openly recognized the country's population crisis and its implications for Japan's economy. He said Japan was "on the brink of being unable to maintain social functions" due to the falling birth rate. In a policy address to lawmakers, Fumio Kishida said it was a case of solving the issue "now or never" and that it "simply cannot wait any longer. In thinking of the sustainability and inclusiveness of our nation's economy and society, we place child-rearing support as our most important policy". Kishida added that he wants the government to double its spending on child-related programs and that a new government agency would be set up in April to focus on the issue.

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