NUNZIUM

News That Matters

21/12/2022 ---- 29/12/2022

Just a month ago, China faced rising socioeconomic pressure due to rigid restrictions against Covid. Lockdowns were frequently in place to limit the virus spread and maintain the sanitary situation under control. However, such measures' economic and social costs have been incredibly high, so the government has recently decided to ease the grip on the virus. The National Health Commission announced that the management of COVID-19 will be downgraded from Class A to Class B from January 8. It means that there will be no more quarantine for people entering the country, and there will be no isolation of COVID-19 cases and the designation of high-risk areas. The government will gradually resume the entry and exit of passenger transport through water and land ports. International passengers coming into the country should still take a nucleic acid test 48 hours before departure. It is worth noting that most countries already have similar measures in place for months. However, immunization in the Chinese population is very low, and most Chinese people have never come in contact with the virus. For this reason, significant pressure on hospitals is already taking place and is expected to grow. The World Health Organization expressed concern about reports of severe disease in China. Around Baoding and Langfang outside Beijing, hospitals have run out of intensive care beds and staff as severe cases surge. Several countries, including Italy, Japan, India and US, are already implementing restrictions for all inbound travellers from China, who now need to show a negative molecular test to travel. The reaction of the Chinese government to such rules is of disappointment, accusing Western countries of disproportionate and inappropriate response to a crisis that, they say, is under control and managed based on a comprehensive analysis. In the meantime, the European and US administrations justify the restrictions with fear of new variants. Every new infection offers a chance for the coronavirus to mutate, and the virus is spreading rapidly in a country with over 1.4 billion people. International relations are also under pressure due to the increasing intensity of the Taiwan crisis. New Chinese military drills came after US President Joe Biden signed the National Defense Authorization Act for Fiscal Year 2023, which marked the first time the US government will finance weapons for the island of Taiwan. The intensity of the drills surpassed those in August. They showed that the Chinese army could organize large-scale exercises repeatedly and at any time. To make things even worse, at the same time, China and Russia were holding joint naval drills in the East China Sea, proving the capability of the Chinese to conduct multiple major military activities in various regions simultaneously. Not the best premises for the upcoming year 2023, in which, hopefully, major powers will learn to collaborate instead of continuously raising international tension.

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In the last few days, record-low temperatures have been registered in large territories of Canada and the US. A powerful and prolonged winter storm brought strong winds and snow in incredible amounts. The scope of the storm has been unprecedented, stretching from Canada as far south as the Rio Grande. The snowfall and blizzard conditions made roads impassable, froze power substations and left more than a dozen dead. At least 38 deaths have now been linked to this severe Arctic freeze. Storm-related deaths were reported in Vermont, Ohio, Missouri, Wisconsin, Kansas, and Colorado. South Florida's temperatures dropped so low that iguanas froze and fell from trees. Over 200'000 people were left without power, with their homes covered in snow and ice. Thousands of flights have been cancelled, preventing many people from reaching their families at Christmas. The western US state of Montana is the worst hit by the cold, with temperatures dropping to -45C. Atlanta and Tallahassee, Florida, were forecast to have their coldest temperature recorded on December 24. Such an event is so rare that it should happen once in a hundred years. However, it is not the first potent and extreme weather event this year. The whole northern hemisphere was hit earlier in the summer by record-high temperatures and droughts. Recently, studies published by eminent climatologists demonstrated that the effects of global warming are to increase the frequency of extreme events. May this recent storm also be a consequence of climate change?

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The FDA has approved Tocilizumab - also known as Actemra and commercialized by Roche Genentech - for treating hospitalized COVID-19 patients. The treatment is for individuals who receive corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation or oxygenation. Tocilizumab is the first FDA-approved monoclonal antibody treatment for COVID-19, recommended for use as a single intravenous injection. Scientists evaluated Tocilizumab for the treatment of COVID-19 in 4 studies in more than 5500 individuals who were hospitalized. The studies showed that Tocilizumab may improve outcomes in individuals receiving corticosteroids and requiring supplemental oxygen or breathing support. There were no new warnings or precautions related to Tocilizumab noted in the trials, with the most common adverse events being anxiety, constipation, diarrhoea, hypertension, insomnia, nausea, and urinary tract infection. More than one million people hospitalized with COVID-19 have been treated with Actemra worldwide since the pandemic's beginning. Tocilizumab has been approved for use for COVID-19 in the United States, European Union, Japan, the United Kingdom, New Zealand, Russia, and Brazil. It is also provisionally approved in Australia and authorized for emergency use in Ghana, Mexico, and Korea for individuals hospitalized with severe or critical COVID-19. The World Health Organization has also recommended and prequalified the drug.

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Earlier this year, the environmental issues have been growing, ranging from devastating floods to extreme heat and drought in the northern hemisphere. The preservation of biodiversity is crucial to sustaining human life on Earth. On this topic, countries have reunited in Montreal, Canada, from December 7 to 19 at the UN COP15 conference. The conference was presided over by China. The premises of this meeting called for prompt action to preserve biodiversity: the latest WWF's Living Planet Report warned that global wildlife populations declined by 69% on average from 1970 to 2018. The accelerating loss of nature has already impacted human well-being and economies. Healthy ecosystems also play indispensable roles in tackling climate change, and biodiversity loss weakens our resilience. In response, nations agreed on four goals and 23 targets to protect biodiversity. The four goals are: (1) to maintain genetic biodiversity, increase the natural ecosystem's areas and reduce extinction rate and risk tenfold (2) to support the restoration and maintenance of biodiversity (3) to share the monetary and non-monetary benefits equitably from utilizing genetic resources, including with indigenous populations and local communities (4) to guarantee adequate means of implementation, including financial resources, capacity-building, and technical and scientific cooperation. A few of the 23 targets for 2030 supporting these goals are undoubtedly relevant. It is agreed to reach the conservation of at least 30% of the world's lands, inland waters, coastal areas and oceans (today, only 17% and 10% of the world's terrestrial and marine areas are under protection). Further, a target mentions reducing the loss of areas of high biodiversity importance to near zero, including ecosystems of high ecological integrity. It is also agreed to cut global food waste in half and reduce overconsumption and waste generation. Financial targets also mentioned phasing out subsidies that harm biodiversity by at least $500 billion per year while mobilizing by 2030 at least $200 billion per year in domestic and international biodiversity-related funding from all sources – public and private. Although all the targets agreed upon in Montreal are impressive, it is fair to question if they will be achieved. In fact, in 2002, nations committed "to achieve by 2010 a significant reduction of the current rate of biodiversity loss". They failed. In 2010 they met in Japan and agreed on a new plan, which included the 20 Aichi Targets. But not one of these targets was fully satisfied by the 2020 deadline. It is worth noting that, being these targets non-binding by law, they are rather guidelines to support objectives. Despite the ambition demonstrated at COP15 leaving hope, it remains true that just earlier this year, a monumental occasion to protect biodiversity failed miserably. At the end of last August, after 15 years of negotiations, nations could not agree on a binding pact to preserve Earth's oceans' biodiversity in another UN meeting in New York - probably the biggest of the lost occasions to preserve our marine ecosystems.

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