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19/11/2022 ---- 21/11/2022

The Climate Change Conference of the Parties (COP) is where the United Nations come together to act towards achieving the world's collective climate goals agreed upon in the Paris Agreement. The Paris Agreement is a legally binding international treaty on climate change. It was adopted by 196 Parties at COP 21 in Paris on December 12 2015. Its goal is to limit global warming to below 2, preferably to 1.5 degrees Celsius, compared to pre-industrial levels. The Paris Agreement was a landmark because, for the first time, a binding agreement brings all nations into a common cause to undertake ambitious efforts to combat climate change and adapt to its effects. COP27 took place from 6 to November 18 2022, in Sharm el-Sheikh, Egypt. Building on the outcomes and momentum of COP26 in Glasgow last year, nations were expected to demonstrate at COP27 that they are in a new era of implementation by turning their commitments into action. COP27 came at a particular historical moment, where the ongoing energy crisis is forcing some nations to increase the use of fossil fuels to produce electricity and heating. Therefore, at COP27, it was impossible to reach a joint statement of severe actions to reduce the use of fossils. This fact was interpreted as alarming in the news worldwide, which depicted the event as inconclusive and marginal. However, in the COP27 final statement, some conclusions may help deal with future climate change. First, it is acknowledged that climate change is a common concern of humankind. Nations should address it promptly while guaranteeing minimal economic impact and human rights, especially indigenous people, children, and the disabled. The importance of ensuring the integrity of all ecosystems, including the forests and the ocean, is noted. It is recognized that some food production systems are also prone to adverse impacts from climate change and that action against such change would aim to safeguard food security and end hunger. It is noted the importance of protecting and preserve water systems. It is stressed that the challenging geopolitical situation and its impact on the energy, food and economy should not be used as a pretext for backtracking, backsliding or de-prioritizing climate action. The limit of 1.5 degrees Celsius temperature rise is reiterated, and the efforts once more confirmed to avoid surpassing such a threshold. Despite recognizing the negative impact of the energy crisis and geopolitical situation on the fight against climate change, a decision has yet to be formulated on the topic. It is iterated that, to meet the 1.5 degrees goal, rapid and sustained reductions in global greenhouse gas emissions of 43 per cent by 2030 relative to the 2019 level is needed. The growing gravity and frequency of loss and damage associated with the adverse effects of climate change are recognized in all regions. It results in devastating economic and non-economic losses, including forced displacement and impacts on cultural heritage, human mobility, and local communities' lives and livelihoods. At COP27, it was confirmed for the first time the importance of an adequate and effective response to loss and damage through solidarity among nations. Matters relating to responding to loss and damage associated with the adverse effects of climate change led to decisions on funding arrangements, including supporting developing countries in catalyzing technical assistance for the implementation of approaches at the local, national and regional levels. Such agreement is the most important achievement at COP27 since rich countries, which will contribute financially to the mechanism, had long opposed its concept. It is estimated that USD 4 trillion per year needs to be invested in renewable energy up until 2030 to reach net zero emissions by 2050. It is noted with concern that the current investment rate is below one-third of what is needed. Climate change is increasingly a threat impacting our lives as humans, and a race is ongoing to save our planet and its ecosystems. In COP27, the closing words of the UN Secretary-General António Guterres: "Together, let's not relent in the fight for climate justice and climate ambition. We can and must win this battle for our lives."

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Trillions of microorganisms, including bacteria, viruses and fungi, inhabit our bodies. Even though they colonize all of our body surfaces, such as skin, lungs, mouth, genital and urinary tract, the majority of them camp out in our gut. We refer to these microorganisms as gut microbiota. Several pieces of evidence show that the gut microbiota influences various processes of our body inside and outside the intestine. For example, they help digestion, protect against pathogens, make vitamins, influence the function of our immune system and maintain a balance between health and disease. A recent study support changes in the composition of the gut microbiota as a potential contributor to Parkinson’s. Parkinson’s is a neurodegenerative disorder characterized by a progressive loss of neurons in the brain due to a misfolding and clumping of the alpha-synuclein protein. Such toxic aggregates promote damage to specialized neurons, also called dopaminergic neurons, therefore, triggering disease symptoms such as tremors, slow movements, rigid muscles, impaired balance and loss of automatics movements. Studies in mice suggest that alpha-synuclein clumps can form in the neurons located in the gut’s mucosal layer and spread in the brain, causing changes in dopaminergic neurons and eventually causing Parkinson’s. Further studies are needed to understand whether this evidence can be translated into humans. Overall, it is important to say that many factors, including genetics, the use of antibiotics, environment, lifestyle, and diet, can influence the composition of the gut microbiota and, therefore, the susceptibility to diseases. As more and more evidence suggests that gut microbiota is an important regulator for human health, controlling it may be one of the next frontiers in medicine.

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