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29/09/2022 ---- 04/10/2022

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04.10.2022
THEME: WORLD

Swedish paleogeneticist Svante Pääbo wins 2022 Nobel Prize for Physiology or Medicine

Dr. Svante Pääbo (Swedish - 67), founder of the Max Planck Institute for Evolutionary Anthropology in Germany and adjunct professor at the Okinawa Institute of Science and Technology, won the 2022 Nobel Prize for Physiology or Medicine. His most important contribution to science was the sequencing of the genome of the Neanderthal, an extinct relative of present-day humans. Dr. Pääbo and his team found that the modern human - Homo Sapiens - inherited some genes from these now exinct hominis. This ancient flow of genes to present-day humans has physiological relevance today, for example affecting how our immune system reacts to infections. The anatomically modern human - Homo Sapiens - first appeared in Africa approximately 300,000 years ago, while our closest known relatives - Neanderthals - developed outside Africa and populated Europe and Western Asia from around 400,000 years until 30,000 years ago, at which point they went extinct. About 70,000 years ago, groups of Homo Sapiens migrated from Africa to the Middle East and from there they spread to the rest of the world. Homo sapiens and Neanderthals thus coexisted in large parts of Eurasia for tens of thousands of years. The research of Dr. Pääbo has proven that such coexistence may have been closer than previously thought.

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03.10.2022
THEME: POLITICS

Brazil elections took place in a violent climate: Lula is favourite after first ballot with 5% margin

More than 156 million Brazilians - those eligible to vote - were called to elect the new president and several local authorities on Sunday, October 2. To win at this first ballot a candidate must collect more than 50% consensus. A second round is foreseen otherwise. These elections, which see two main candidates - Lula and Bolsonaro - radically opposite in almost every aspect of their politics, are characterized by an extreme climate of violence. Recent events include shootings at public places, the murder of a politician, and even explosives thrown at the crowd of a political rally. Due to the tense climate, the two candidates have been seen constantly escorted by security or police, even wearing bulletproof vests. Bolsonaro - the head of the Liberal Party, now 67 - would be re-elected with a victory. His campaign focused on privatization of public companies, lowering energy prices, increasing mining activities, and welfare in continuation with his previous government (Auxilio Brasil). Lula, now 76, is representing the Worker’s Party and would also achieve re-election in the event of a victory: he governed before in two consecutive terms until 2010. He left office with a very high approval rating, and he is largely credited for lifting many Brazilians from extreme poverty with the “Bolsa Familia” welfare program. He focused his campaign on getting Bolsonaro out of office and highlighted his past achievements throughout the campaign. However, he was involved in the wide-ranging “Operation Car Wash” investigation and was convicted for corruption and money laundering in 2017. But after serving less than two years, a Supreme Court Justice annulled Lula’s conviction in March 2021, clearing the way for him to run for president for the sixth time. Lula obtained more than 48% votes in the first round and will face Bolsonaro - 43% - on October 30 in the final election round.

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01.10.2022
THEME: HEALTH

Recent research finds that the brain “rewires” in phases during adulthood

With more than 80 billion interconnected neuronal cells, the human brain is one of the yet unsolved big mysteries of science. In popular knowledge it is accepted that the brain goes through significant changes in childhood: this is supported by evident milestones such as learning to walk, speak, paint, etc… However, brain development is often commonly thought of as a process that, starting at the youngest age, reaches a mature state in young adults and only in old age - eventually - degrades by an act of diseases such as dementia or Alzheimer’s. Recent scientific research is instead pointing to a completely different understanding. The structural, functional, and metabolic changes don’t stop in the early years and continue throughout adulthood in more than one distinct phase. A “refinement phase” takes place around the third and fourth decade of life: the executive function and attention, such as the ability to think abstractly, reason, and problem-solve will peak at this point before further changing. Around the fifth decade of life, our brains start to undergo a radical "rewiring" that results in a more integrated and connected network. Older adults display reduced activity in consolidating or learning concepts, but an improved activity in associating what is already learned. Such change likely results from the necessity to function with reduced resources and aging neurons. Overall, tasks relying on predominantly known processes are less impacted by age or may even increase slightly - such as vocabulary and general knowledge. Evidence also indicated that the variability among individuals can be large: a proper diet, regular exercise, and a healthy lifestyle can keep the mind in good working order and put networking changes on hold, sometimes well into old age. Further understanding of these matters may, in the future, positively evolve our societies as currently adult individuals are considered equals - by organizational and representative organs - independently of their age.

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30.09.2022
THEME: POLITICS

Nations witness unprecedented attacks to gas pipelines while Russia annexes Ukraine territories

Today September 30 Putin confirmed the annexation of Donetsk, Kherson, Luhansk, and Zaporizhzhia in a televised ceremony in the Kremlin's St. George's Hal, justified by the so-called “referendums”. He added that “….(they) are becoming our citizens forever” and that Russia “will defend its land with all the means available”. Ukraine and the West have renounced the vote as a sham and said they will never recognize the Ukrainian regions as being part of Russia. Reactions are escalating with the EU promising more opposition and economic sanctions, Ukraine promising continued military effort, and the US and Russia exchanging threats. Finland announced the closure of its borders to Russian tourists starting midnight. Additional tension is due to four gas leaks that occurred on the Nord Stream 1 and 2 pipelines on Monday. They were preceded by two large explosions that were registered by seismologists, indicating that it was a deliberate attack. To date, no pointers have yet emerged as to who might have done it and why. The damage now likely prevents transporting any gas to Europe even if the political situation changes. German security agencies are concerned that Nord Stream 1 may become unusable forever and the EU is now investigating the incident and promising countermeasures. Naval forces have been deployed from the Baltic to the Mediterranean seas to protect continental infrastructures. While NATO and US accused Russia, the Kremlin rejected accusations saying it was not in Russia's interest to stop the gas flow through the pipelines. Dmitry Peskov (Press Secretary) and Sergey Lavrov (Foreign Affairs) declared investigations are needed and that Russia would call for a UN Security Council over the matter. Putin himself defined it as an "unprecedented sabotage" and "an act of international terrorism”, accusing the US and saying that “it is obvious to everyone who did it”. In the meantime, Germany's government says it will spend up to €200 billion to help consumers and businesses cope with rising energy prices: a decision likely to spread through the EU countries. Further, a final measure of the EU commission on the price cap on energy imports will also be decided or rejected by mid-October.

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29.09.2022
THEME: HEALTH

Historic moment for Alzheimer's treatment: an experimental drug demonstrated slowing the disease’s progression

On Wednesday the experimental drug “lecanemab”, developed by Eisai (Japan) and Biogen (USA), has been declared efficient as a result of a large phase 3 clinical study involving 1795 patients with early Alzheimer’s disease. With high statistical significance, lecanemab has shown a reduction in clinical decline in patients. It has been shown that the drug slowed the progress of the disease by 27% compared to the placebo. Toxic plaques made of “amyloid-beta” proteins are considered the probable cause of Alzheimer’s disease. The drug reduced the number of toxic plaques in the brain and slowed the decline in memory and ability to perform daily tasks. Lecanemab has been the first one able to successfully slow cognitive decline in Alzheimer’s patients. This is a great achievement for science and medicine, which now offer hope for patients and their families desperate for effective treatment. The multinational pharmacology company Roche, together with Genentech and the Swiss laboratory AC Immune is developing a second drug based on the same principle, which hopefully will even reinforce future treatments.

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